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November 30, 2012--------News Archive

Jigsaw Mutation Critical Piece of Notch Pathway Puzzle
The Notch pathway helps determine cell fate, differentiation and proliferation. How it accomplishes these tasks has been a puzzle. But now research has identified a key – a specific domain within Notch critical to determining which ligand Notch will bind with

Biology Behind Brain Development Disorder
Studies in mice confirm that mutations in the gene, UBE3B, cause a rare genetic disorder in children

Scientists Describe Genetic Signature Of A Vital Set Of Neurons
Scientists have identified two genes involved in establishing the neuronal circuits required for breathing

November 29, 2012--------News Archive

Women 16 to 49 at Risk From Multiple Pollutants
In an analysis of thousands of U.S. women of childbearing age, Brown University researchers found that most exceeded the median blood level for two or more of three environmental pollutants that could harm brain development in fetuses and babies: lead, mercury, and polychlorinated biphenyls (PCBs)

Research Sheds New Light on Virus Associated with Developmental Delays and Deafness, Offering Hope for Treatment
Researchers found that as stem cells and other primitive cells mature into neurons, they become more susceptible to HCMV, which could allow them to find effective treatments for the virus and to prevent its potentially devastating consequences

November 28, 2012--------News Archive

Scientists Identify Key Gene for Male Sex Determination
Loss of the gene Gadd45g results in complete sex reversal of male mice, making them appear female. Scientists have uncovered a novel signaling cascade, which acts early in development to induce gonad formation in males

Gene Linked to Respiratory Distress in Babies
Some infants are more susceptible to potentially life-threatening breathing problems after birth, and rare, inherited DNA differences may explain why

Massive Genomics Project Answers Questions, Poses New Ones In Health, Genetics and Aging
Initial research findings focus on telomere trends within ethnicity, socioeconomic status, and lifestyle revealing that people with the shortest telomeres really do have a date with the Grim Reaper – according to the largest and most diverse genomics, health and longevity project in the nation

November 27, 2012--------News Archive

Advancing Use of Stem Cells in Personalized Medicine
Johns Hopkins researchers report concrete steps in the use of human stem cells to test how diseased cells respond to drugs. Their success highlights a pathway toward faster, cheaper drug development for some genetic illnesses, as well as the ability to pre-test a therapy's safety and effectiveness on cultured clones of a patient's own cells

Putrescine Water - Fountain of Youth for Eggs?
Ottawa scientist has discovered a critical reason why women experience fertility problems as they get older. Putrescine could reduce the rate at which middle-aged women produce eggs with the incorrect number of chromosomes, the leading cause of reduced fertility and increases in miscarriages and congenital birth defects

Better Blood Transfusions for Preterm Babies
Results of new research from the University of Adelaide are a promising step forward in helping to improve the quality of life-saving blood transfusions for preterm babies, by reducing the likelihood of adverse inflammatory responses to the blood

November 26, 2012--------News Archive

Scientists Solve Birth and Migration of Cortex 'Chandelier' Cells
The cerebral cortex of the human brain has been called "the crowning achievement of evolution." Ironically, it is so complex that even our greatest minds and most sophisticated science are only now beginning to understand how it organizes itself in early development, and how its many cell types function together as circuits

Team Identifies Gatekeeper Protein, New Details on Mitochondria
Researchers have identified a protein that serves as a gatekeeper for controlling the rush of calcium into the cell’s power source, the mitochondria. Without this calcium spigot under control, calcium levels can run amok, contributing to cardiovascular disease, diabetes and neurodegeneration

Alzheimer’s Disease in Mice Alleviated
Pathological changes typical of Alzheimer’s disease were significantly reduced in mice by blockade of an immune system transmitter

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