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Pregnancy Timeline by SemestersFemale Reproductive SystemFertilizationThe Appearance of SomitesFirst TrimesterSecond TrimesterThird TrimesterFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterDevelopmental Timeline
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September 17, 2012--------News Archive Return to: News Alerts


No safe level of alcohol consumption during pregnancy has been identified.

WHO Child Growth Charts

       

Maternal Drinking During Pregnancy Can Damage the Fetal Brain

A new study has examined the impact of maternal drinking on fetal habituation - or learning abilities - while still residing in the mother's womb

Results showed that those fetuses exposed to heavy binge drinking required significantly more trials to habituate, and also exhibited a greater variability in test performance.


Habituation refers to the ability of an organism to stop responding to repeated stimulation.


While it has become clear that drinking during pregnancy can damage the fetal central nervous system, these outcomes can also be influenced by factors such as timing, type, amount, and duration of alcohol exposure. Furthermore, most studies of fetal neurobehavioral effects have been conducted during the postnatal period.


This study is the first of its kind, examining alcohol's effects on fetal brain function – information processing and stability of performance – at the time of exposure to alcohol.


Results will be published in the December 2012 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View.

"When examined after birth, individuals who have been prenatally exposed to alcohol exhibit a wide range of behaviours that are indicative of central nervous system dysfunction," explained Peter G. Hepper, a professor of psychology at Queen's University of Belfast as well as corresponding author for the study. "These can include poorer abilities to learn, deficits in attention, poorer abilities to plan and organize, and an inability to learn about the consequences of actions. As a consequence, they may demonstrate behavioural difficulties and social problems which might lead to problems at school, and often 'trouble with the law.'"

"This study used a process of habituation, which is the ability of an organism to stop responding to repeated stimulation," explained Leo Leader, a senior lecturer in the School of Women's and Children's Health at the University of New South Wales. "This reflects the ability of the central nervous system to learn to recognize a particular stimulus. It is widely accepted that habituation represents a basic form of learning. Previous research has shown that the normal human fetus habituates, but habituation rates are altered if the fetus is exposed to reduced oxygen levels, maternal smoking, maternal sedatives, and impaired fetal growth."

"There have been no other studies looking at the habituation or learning abilities of the individual at the time they are being exposed to alcohol, that is, in their mother's womb," said Hepper. "Essentially, we played a loud two-second sound to the fetus via a speaker on the mother's abdomen. We watched using ultrasound whether the fetus moved, jumped or startled to the sound. The sound was repeated every five seconds and the response of the fetus recorded each time. As the sounds are repeated, the fetus's response got weaker and eventually, after a number of sound presentations, disappeared. At this point the fetus is said to have habituated."

Hepper and his colleagues examined 78 non-smoking mothers with normal, apparently healthy, single pregnancies from the Royal Jubilee Maternity Service in Belfast. Details of the mothers' alcohol consumption were obtained through questionnaires completed at 12 to 14 and 18 to 20 weeks gestation as well as semi-structured interviews at 34 weeks of gestation.

Following identification of the mothers' drinking habits, five groups of fetuses were examined: control (n=30), moderate amounts consumed during the week (n=15), moderate amounts consumed during a binge period (n=13), heavy amounts consumed during the week (n=9), and heavy amounts consumed during a binge period (n=11).

Fetal performance was examined on three occasions, seven days apart, beginning at 35 weeks of gestation.


"We have demonstrated that at the time of exposure,
alcohol is affecting a fundamental psychological
process known as habituation that underlies many
of our more complex psychological abilities."

Habituation is a basic but high level
psychological process that controls
information flow in the brain.

Peter G. Hepper, Queen's University of Belfast


Hepper: "For example, when you enter a room for the first time you may be aware of the loud ticking of a clock. However, very quickly you will no longer 'hear' or pay attention to the ticking. The process of habituation has told the brain the ticking]is a non- threatening stimulus and switches attention to other things of merit.

How good we are at this is a measure of how well we can process information. The quicker the habituation process, the better able individuals are to process information by turning off attention to irrelevant non-changing stimuli, and focusing attention and awareness on new potentially threatening stimuli."


"Results showed that the fetuses of mothers
who binge drink five to 10 drinks per week,
or drink more than 20 drinks a week drunk evenly,
or binge over two to three days
take significantly longer to habituate.

The study also showed that binge drinking
was associated with more variability of the fetus to learn.

For normal learning and development,
the fetal brain requires stability.
This result implies that binge drinking
impaired this function."

Leo Leader, School of Women's and Children's Health,
University of New South Wales


Hepper agreed: "One often ignored element of our brain function is its stability in functioning. That is, our brain operates today the same as it did yesterday and will operate the same tomorrow. This is fundamental to our ability to exist and function in the world.

Our study demonstrated that when exposed to alcohol there was increased variability in the brain's ability to habituate. The brain didn't perform the same. By observing these behavioural effects before birth, we can start to identify the areas of brain affected by alcohol and possibly develop treatments.

Moreover, by identifying the presence of alcohol-induced problems before birth, it will be possible to implement better management strategies much earlier and hopefully improve outcomes."


Both Hepper and Leader noted that no safe level of alcohol consumption during pregnancy has been identified.


"One 'oddity' of prenatal exposure to alcohol is there are large individual differences in its effects," said Hepper. "Some individuals whose mothers drink heavily may exhibit few effects whilst others whose mothers drink less may exhibit much greater effects. By observing the behaviour of the fetus it will be possible to ascertain which and by how much individuals have been affected by exposure to alcohol. To be safe, however, no drinking during pregnancy would be wise."

Alcoholism: Clinical & Experimental Research (ACER) is the official journal of the Research Society on Alcoholism and the International Society for Biomedical Research on Alcoholism. Co-authors of the ACER paper, "Fetal Brain Function in Response to Maternal Alcohol Consumption: Early Evidence of Damage," were James C. Dornan of the Royal Jubilee Maternity Services at Queen's University of Belfast; and Catherine Lynch of the School of Psychology at Queen's University of Belfast. The study was funded by the Department of Health and Social Services and Public Safety of Northern Ireland, and the National Institute on Alcohol Abuse and Alcoholism. This release is supported by the Addiction Technology Transfer Center Network at. http://www.ATTCnetwork.org.

Original article: http://www.eurekalert.org/pub_releases/2012-09/ace-mdd090712.php