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December 10, 2012--------News Archive Return to: News Alerts


Without the key molecule, NOMPC, newly hatched fruit flies
are insensitive to any amount of gentle stroking.








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Secrets of Gentle Touch Revealed

In fruit flies, UCSF researchers uncover the molecular basis of our most mysterious physical sense

Stroke the soft body of a newborn fruit fly larva ever-so-gently with a freshly plucked eyelash, and it will respond to the tickle by altering its movement—an observation that has helped scientists at the University of California, San Francisco (UCSF) uncover the molecular basis of gentle touch, one of the most fundamental but least well understood of our senses.

Our ability to sense gentle touch is known to develop early and to remain ever-present in our lives, from the first loving caresses our mothers lavish on us as newborns to the fading tingle we feel as our lives slip away. But until now, scientists have not known exactly how humans and other organisms perceive such sensations.

The article is published online this week in the journal Nature.


The team has identified the exact subset of nerve cells
responsible for communicating gentle touch to the
brains of Drosophila larvae—called class III neurons.

They also uncovered a particular protein called NOMPC,
which is found abundantly at the spiky ends of the nerve
s and appears to be critical for sensing gentle touch in flies.

Without this key molecule, the team discovered, flies
are insensitive to any amount of eyelash stroking,
and if NOMPC is inserted into neurons that cannot
sense gentle touch, those neurons
gain the ability to do so.


"NOMPC is sufficient to confer sensitivity to gentle touch," said Yuh Nung Jan, PhD, a professor of physiology, biochemistry and biophysics and a Howard Hughes Medical Institute investigator at UCSF. Jan led the study with his wife Lily Jan, PhD, who is also a UCSF professor and a Howard Hughes Medical Institute investigator.

The work sheds light on a poorly understood yet fundamental sense through which humans experience the world and derive pleasure and comfort.

Jan added that while the new work reveals much, many unanswered questions remain, including the exact mechanism through which NOMPC detects mechanical force and the identity of the analogous human molecules that confer gentle touch sensitivity in people.

The discovery is a good example of basic brain research paving the way toward answering such questions.

Why is Touch Still Such a Mystery?

Though it is fundamental to our experience of the world, our sense of gentle touch has been the least well understood of our senses scientifically, because, unlike with vision or taste, scientists have not known the identity of the molecules that mediate it.

Scientists generally feel that, like those other senses, the sense of touch is governed by peripheral nerve fibers stretching from the spine to nerve endings all over the body. Special molecules in these nerve endings detect the mechanical movement of the skin surrounding them when it is touched, and they respond by opening and allowing ions to rush in. The nerve cell registers this response, and if the signal is strong enough, it will fire, signaling the gentle touch to the brain.

What has been missing from the picture, however, are the details of this process. The new finding is a milestone in that it defines the exact nerves and uncovers the identity of the NOMPC channel, one of the major molecular players involved—at least in flies.


The Jans and their colleagues made this discovery
through an unusual route. They were looking at the
basic physiology of the developing fruit fly,
examining how class III neurons develop in larvae.

They noticed that when these cells developed
in insects, their nerve endings would always
branch into spiky "dendrites."

And when examined closely, they found the
protein NOMPC was abundant at the spiky ends.

Then after examining a genetically engineered fly,
with non-functioning NOMPC, they found
that it was insensitive to gentle touch.

They went on to find that they could induce touch
sensitivity, in neurons that do not normally respond
to gentle touch, by inserting copies of the
NOMPC protein into those neurons.


The article, "Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation" is authored by Zhiqiang Yan, Wei Zhang, Ye He, David Gorczyca, Yang Xiang, Li E. Cheng, Shan Meltzer, Lily Yeh Jan and Yuh Nung Jan. It appears as an Advanced Online Publication by the journal Nature on December 9, 2012.

This work was funded by the National Institutes of Health via grant #R37NS040929 and #5R01MH084234; by the Howard Hughes Medical Institute; and through two Long-Term Fellowships from the Human Frontier Science Program.

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.

Original article:http://www.eurekalert.org/pub_releases/2012-12/uoc--sog120512.php