Reproduction and Life Span Intertwined
Removing a roundworm's germ cells prolongs the animal's life
The gonad is well known to be important for reproduction but also affects animal life span. Removal of germ cells the sperm and egg producing cells increases longevity of the roundworm Caenorhabditis elegans. However, the underlying molecular mechanisms were a mystery.
Now scientists at the Cologne-based Max Planck
Institute for Biology of Ageing, have discovered
that germ cell removal flips a “molecular switch”
that extends the life span by using components
of a “developmental clock.”
The roundworm Caenorhabditis elegans is a commonly used model organism in the field of ageing research. It develops from an egg to adult through four larval stages. These developmental stages are controlled by a developmental clock.
Yidong Shen and colleagues working in the department
of Director Adam Antebi used a laser to remove
the germ cells.
They found that the remaining gonadal cells trigger
production of a steroid hormone called dafachronic acid.
Dafachronic acid activates so-called microRNAs,
which work as tiny molecular switches causing changes
in gene expression that promote longevity.
Interestingly, this same steroid hormone-microRNA
switch was previously shown by Antebi and colleagues
to be part of the developmental clock. Thus, the loss
of the germ cells ultimately causes the worm to use
developmental timers to put in motion
a life-prolonging programme.
In uncovering these findings, the Max Planck scientists have added some more pieces to the puzzle of describing and understanding how longevity is regulated.
The question now is whether humans also possess
a similar microRNA-controlled switch system.
Abstract found on the Max Planc Institute for Biology of Ageing site - "A "molecular switch" regulates developmental processes in the roundworm."
Full citation available NIH Public Access.
Original article: http://www.mpg.de/6696558/reproduction-lifespan