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December 24, 2012--------News Archive Return to: News Alerts


"The study shows that the DNA sequence, in some regions of the human genome, is quite volatile and can mutate ten times more frequently than the rest of the genome.

Genes that are linked to autism and a variety of other disorders
have a particularly strong tendency to mutate.



WHO Child Growth Charts

       

Genomic 'Hotspots' Offer Clues to Causes of Autism, Other Disorders

An international team, led by researchers from the University of California, San Diego School of Medicine, has discovered that "random" mutations in the genome are not quite so random after all

Their study, published in the journal Cell on December 21, shows that the DNA sequence in some regions of the human genome is quite volatile and can mutate ten times more frequently than the rest of the genome. Genes that are linked to autism and a variety of other disorders have a particularly strong tendency to mutate.

Clusters of mutations or "hotspots" are not unique to the autism genome but instead are an intrinsic characteristic of the human genome, according to principal investigator Jonathan Sebat, PhD, professor of psychiatry and cellular and molecule medicine, and chief of the Beyster Center for Molecular Genomics of Neuropsychiatric Diseases at UC San Diego.


"Our findings provide some insights into the underlying
basis of autism—that, surprisingly, the genome is not
shy about tinkering with its important genes
.

To the contrary, disease-causing genes
tend to be hypermutable."

Jonathan Sebat, PhD
professor psychiatry and cellular and molecule medicine
Chief, Beyster Center for Molecular Genomics
of Neuropsychiatric Diseases, UC San Diego


Sebat and collaborators from Rady Children's Hospital-San Diego and BGI genome center in China sequenced the complete genomes of identical twins with autism spectrum disorder and their parents. When they compared the genomes of the twins to the genomes of their parents, the scientists identified many "germline" mutations (genetic variants that were present in both twins but not present in their mother or father).

Nearly 600 germline mutations – out of a total of 6 billion base pairs – were detected in the 10 pairs of identical twins sequenced in the study. An average of 60 mutations was detected in each child.

"The total number of mutations that we found was not surprising," said Sebat, "it's exactly what we would expect based on the normal human mutation rate." What the authors did find surprising was that mutations tended to cluster in certain regions of the genome. When the scientists looked carefully at the sites of mutation, they were able to determine the reasons why some genomic regions are "hot" while other regions are cold.

"Mutability could be explained by intrinsic properties of the genome," said UC San Diego postdoctoral researcher Jacob Michaelson, lead author of the study. "We could accurately predict the mutation rate of a gene based on the local DNA sequence and its chromatin structure, meaning the way that the DNA is packaged."

The researchers also observed some remarkable examples of mutation clustering in an individual child, where a shower of mutations occurred all at once. "When multiple mutations occur in the same place, such an event has a greater chance of disrupting a gene," said Michaelson.


The researchers surmised that hypermutable genes
could be relevant to disease. When they predicted
the mutation rates for genes, the authors found that
genes that have been linked to autism were more
mutable than the average gene, suggesting that some
of the genetic culprits that contribute to autism
are mutation hotspots.

The authors observed a similar trend
for other disease genes.

Genes associated with dominant disorders
tended to be highly mutable, while mutation rates
were lower for genes associated with complex traits.


Sebat: "We plan to focus on these mutation hotspots in our future studies. Sequencing these regions in larger numbers of patients could enable us to identify more of the genetic risk factors for autism."

The researchers at UC San Diego and Rady Children's Hospital are actively recruiting families through a genetic study called "REACH," that is funded by the Simons Foundation. For more information about this study or to get involved in autism research at UC San Diego, visit http://reachproject.ucsd.edu

Additional contributors to the published study include co-first authors Yujian Shi and Hancheng Zheng, BGI-Shenzhen, China, and Madhusudan Gujral and Dheeraj Malhotra, UC San Diego; Douglas Greer, Abhishek Bhandari, Wenting Wu, Roser Corominas, Shuli Kang, Guan Ning Lin, Jasper Estabillo, Therese Gadomski, Balvindar Singh, Natacha Akshoomoff, and Lilia M. Iakoucheva, UC San Diego School of Medicine; Xin Jin, BGI-Shenzhen and South China University of Technology, Guangzhou, China; Jian Minghan and Yingrui Li, BGI-Shenzhen; Guangming Liu, National University of Defense Technology, Changsha, Hunan, China and National Supercomputer Center, Tianjim, China; Áine Peoples, UC San Diego and Trinity College, Dublin, Ireland; Amnon Koren and Steven McCarroll, Harvard Medical School; Athurva Gore and Kun Zhang, Department of Bioengineering, UC San Diego; Christina Corsello, Rady Children's Hospital-San Diego; and Jun Wang, BGI-Shenzhen, University of Copenhagen, and the Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark.

The study was funded in part by grants from the National Institutes of Health (MH076431 and HG005725), the Simons Foundation Autism Research Initiative (SFARI 178088), and NIH RO1 HD065288 and NIH RO1 MH091350.

Original article: http://health.ucsd.edu/news/releases/Pages/2012-12-20-genomic-hotspots-and-autism.aspx