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Welcome to The Visible Embryo, a comprehensive educational resource on human development from conception to birth.

The Visible Embryo provides visual references for changes in fetal development throughout pregnancy and can be navigated via fetal development or maternal changes.

The National Institutes of Child Health and Human Development awarded Phase I and Phase II Small Business Innovative Research Grants to develop The Visible Embryo. Initally designed to evaluate the internet as a teaching tool for first year medical students, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than one million visitors each month.

Today, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than 1 million visitors each month. The field of early embryology has grown to include the identification of the stem cell as not only critical to organogenesis in the embryo, but equally critical to organ function and repair in the adult human. The identification and understanding of genetic malfunction, inflammatory responses, and the progression in chronic disease, begins with a grounding in primary cellular and systemic functions manifested in the study of the early embryo.

WHO International Clinical Trials Registry Platform


The World Health Organization (WHO) has created a new Web site to help researchers, doctors and
patients obtain reliable information on high-quality clinical trials. Now you can go to one website and search all registers to identify clinical trial research underway around the world!



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Pregnancy Timeline by SemestersFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresFemale Reproductive SystemEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterSecond TrimesterFirst TrimesterFertilizationDevelopmental Timeline
CLICK ON weeks 0 - 40 and follow along every 2 weeks of fetal development
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Home | Pregnancy Timeline | News Alerts | News Archive May 22, 2013

 
The protein-lipid molecule complex found in breast milk, is known as HAMLET,
which stands for Human Alpha-lactabumin Made Lethal to Tumour cells.






WHO Child Growth Charts

 

 

 

A molecule in human breast milk proves to be successful in killing tumor cells

The molecule has been found to have strong and wide-ranging tumour killing properties when bound to certain lipids. Lipids are molecules like amino acids and carbohydrates, are made up of carbon and hydrogen, help to store energy, and to form biological membranes.

The protein-lipid molecule complex, is known as HAMLET, which stands for Human Alpha-lactabumin Made Lethal to Tumour cells. It has been proven to be safe and effective as it only targets tumour cells, leaving healthy human cells intact.


HAMLET has most recently been shown to successfully suppress colon cancer in laboratory mice.

The scientists have also successfully identified and isolated specific components of HAMLET called peptide-oleate bound forms, which have the tumour-killing effect. Peptides are short chain amino acids commonly found in the human body.


These latest breakthroughs are led by Professor Catharina Svanborg and Dr Manoj Puthia from Lund University, Sweden, and Professor Gerhard Grüber from NTU’s School of Biological Sciences. The HAMLET complex was first discovered by Professor Svanborg’s research group.

The findings were published recently in Gut and in PLoS ONE, two top ranking peer-reviewed academic journals. The researchers found that laboratory mice genetically modified to develop colon cancer, were protected to a large extent when fed with HAMLET-laced water. This suggested that HAMLET was killing emerging tumour cells faster than these cells could grow and proliferate.

On the new concept of a synthetic version of the tumour-killing molecule, Prof Grüber said, “By studying the original protein, we have and will continue to identify key components to make a synthetic peptide, a short-chain amino acid, carrying the properties of HAMLET and yet more resilient than the original protein complex.”

“By synthetically constructing the key components, this helps the peptide to be much more resilient and to ‘survive’ in different environments, such as in the human body or in drinking water, which is an ideal delivery medium, before it reaches its tumour target.”

The ability to recreate HAMLET in synthetic form opens up possibilities of turning it into a drug to kill tumours.

Next steps

Prof Svanborg, who is a doctor and a scientist, said she had seen promising results from the human trials using HAMLET in Sweden.

“We are now ready to test HAMLET as a therapeutic and preventive agent in colon cancer, especially in families with the genetic predisposition, where preventive options are limited,” Prof Svanborg said.

“After completing the various clinical trials, we hope to develop a commercially available product for doctors’ use for cancer treatment in the next five to ten years,” she added.

The two lead scientists added that they are also looking to trial HAMLET in Singapore and are in talks with local institutions and industry.

About Nanyang Technological University
A research-intensive public university, Nanyang Technological University (NTU) has 33,500 undergraduate and postgraduate students in the colleges of Engineering, Business, Science, and Humanities, Arts, & Social Sciences. It has a new medical school, the Lee Kong Chian School of Medicine, set up jointly with Imperial College London.

NTU is also home to world-class autonomous institutes – the National Institute of Education, S Rajaratnam School of International Studies, Earth Observatory of Singapore, and Singapore Centre on Environmental Life Sciences Engineering – and various leading research centres such as the Nanyang Environment & Water Research Institute (NEWRI), Energy Research Institute @ NTU (ERI@N) and the Institute on Asian Consumer Insight (ACI).

A fast-growing university with an international outlook, NTU is putting its global stamp on Five Peaks of Excellence: Sustainable Earth, Future Healthcare, New Media, New Silk Road, and Innovation Asia.

Besides the main Yunnan Garden campus, NTU also has a satellite campus in Singapore’s science and tech hub, one-north, and a third campus in Novena, Singapore’s medical district.

For more information, visit www.ntu.edu.sg

Original article: http://media.ntu.edu.sg/NewsReleases/Pages/newsdetail.aspx?news=c9891033-1c64-4839-980b-fcf754f25947