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Welcome to The Visible Embryo, a comprehensive educational resource on human development from conception to birth.

The Visible Embryo provides visual references for changes in fetal development throughout pregnancy and can be navigated via fetal development or maternal changes.

The National Institutes of Child Health and Human Development awarded Phase I and Phase II Small Business Innovative Research Grants to develop The Visible Embryo. Initally designed to evaluate the internet as a teaching tool for first year medical students, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than one million visitors each month.

Today, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than 1 million visitors each month. The field of early embryology has grown to include the identification of the stem cell as not only critical to organogenesis in the embryo, but equally critical to organ function and repair in the adult human. The identification and understanding of genetic malfunction, inflammatory responses, and the progression in chronic disease, begins with a grounding in primary cellular and systemic functions manifested in the study of the early embryo.

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Pregnancy Timeline by SemestersFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresFemale Reproductive SystemEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterSecond TrimesterFirst TrimesterFertilizationDevelopmental Timeline
CLICK ON weeks 0 - 40 and follow along every 2 weeks of fetal development
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Home | Pregnancy Timeline | News Alerts | News Archive June 20, 2013

 


“This is the first true estimate from when we think the process of type 1 diabetes starts ,
and the largest dataset that exists, with over 13,000 children followed from birt
h and over 1,000 children who developed antibodies,”

Anette-Gabriele Ziegler, M.D.





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Autoantibodies in Children Define Early Type 1 Diabetes

Long-term study reveals that multiple islet autoantibodies in young children indicate a high risk of developing type 1 diabetes within 10 years, clarifying the window for potential prevention strategies.

A decade-long JDRF-funded study led by the Institute of Diabetes Research in Helmholtz Zentrum München, Germany, is providing a deeper understanding of the link between autoantibodies and the risk of developing type 1 diabetes (T1D), highlighting the importance of pre-diabetes research into possible preventions for the disease. The study, “Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children,” was published today in The Journal of the American Medical Association.

Researchers in Colorado (DAISY study), Finland (DIPP study), and Germany (BABYDIAB) followed children from infancy until as old as three years old, to determine the presence of islet autoantibodies—markers that indicate the activation of the autoimmune attack on insulin-producing beta cells in the pancreas.


T1D occurs when these beta cells are destroyed, rendering people with the disease unable to produce their own insulin. The new findings reveal that nearly 70 percent of the 585 young children studied (in all three countries) who had two or more autoantibodies developed T1D within 10 years, with 84 percent developing T1D in 15 years.

The study also revealed that 14.5 percent of the 474 children with a single islet autoantibody developed T1D within 10 years, and that progression of the disease was faster for those who showed the presence of antibodies at younger than three years old. The risk for children without autoantibodies was only 0.4 percent by age 15 years.


“This is the first true estimate from when we think the process of type 1 diabetes starts, and the largest dataset that exists, with over 13,000 children followed from birth and over 1,000 children who developed antibodies,” said Anette-Gabriele Ziegler, M.D., director of the Institute of Diabetes Research, who led the study in Germany. “I believe that this sort of data should make us consider whether the status of confirmed multiple islet autoantibodies be used in the staging of type 1 diabetes. This will allow more consideration for intervention necessary to stop or delay progression to the full and irreversible metabolic disease.”

“These findings will help us to better identify children who are at the highest risk for developing type 1 diabetes, and allow scientists to focus prevention efforts on groups who are most likely to become insulin dependent,” said Jessica Dunne, senior scientist at JDRF. “Prevention of type 1 diabetes is a priority for JDRF, and it is work like this that sets the stage for our efforts.”

As a next step, JDRF and its partners are advancing research to develop potential vaccines for T1D and to test compounds that may prevent onset of T1D in those at risk for the disease.

A critical part of that effort is a study funded by the National Institutes of Health (NIH) through the Special Diabetes Program (SDP) called TEDDY (The Environmental Determinants of Diabetes in the Young), which is testing whether factors such as antibiotics, viruses, gut microbes, cows’ milk, deficiency of vitamin D, omega-3s, or other environmental causes are triggers for the onset of the T1D in those at risk. JDRF is a leading advocate for the renewal of the SDP in Congress, which funds $150 million a year in T1D research through the NIH.

About JDRF
JDRF is the leading global organization funding type 1 diabetes (T1D) research. JDRF’s goal is to progressively remove the impact of T1D from people’s lives until we achieve a world without T1D. JDRF collaborates with a wide spectrum of partners and is the only organization with the scientific resources, regulatory influence, and a working plan to better treat, prevent, and eventually cure T1D.

As the largest charitable supporter of T1D research, JDRF is currently sponsoring $530 million in scientific research in 17 countries. In 2012 alone, JDRF provided more than $110 million to T1D research. More than 80 percent of JDRF’s expenditures directly support research and research-related education. In 2012 Forbes magazine named JDRF one of its five All-Star charities, citing the organization’s efficiency and effectiveness.

Original press release:http://jdrf.org/press-releases/new-data-on-islet-autoantibodies-in-young-children-defines-early-type-1-diabetes-development/