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Today, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than 1 million visitors each month. The field of early embryology has grown to include the identification of the stem cell as not only critical to organogenesis in the embryo, but equally critical to organ function and repair in the adult human. The identification and understanding of genetic malfunction, inflammatory responses, and the progression in chronic disease, begins with a grounding in primary cellular and systemic functions manifested in the study of the early embryo.

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Home | Pregnancy Timeline | News Alerts | News Archive June 31, 2013

 
Good glycemic control emerged as an important factor in both the study
transplantation group as well as in the non-transplanted control group.






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Type 2 diabetic bone marrow stem cells reduce insulin use

A study has found patients receiving self-donated — autologous — transplanted bone marrow stem cells require less insulin following cell transplantation.

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line.


"There is growing interest in the scientific community for cellular therapies that use bone marrow-derived cells for the treatment of type 2 diabetes mellitus and its complications. The potential of stem cell therapy for this disease is yet to be fully explored."

Anil Bhansali, PhD, corresponding author professor, head of the Endocrinology Department at the Post Graduate Institute of Medical Education in Chandrigarh, India


The study aim was to evaluate the efficacy and safety of autologous bone marrow-derived transplantation in patients with T2DM who exercised good glycemic control. And it appears to have done just that. Autologous stem cell transplant demonstrated significant reduction in the insulin requirement of patients in this study who were administered cells—but also, a significantly smaller reduction was observed in the insulin requirement of the control group who excercised "a repeated emphasis on life style modification."

"The efficacy and safety of stem cell therapy needs to be established in a greater number of patients and with a longer duration of follow-up," concluded Bhansali and his co-authors. "The data available so far from animal and human studies is encouraging, however, it has enormous limitations."

The researchers recommend determining which type of stem cells —hematopoietic, bone marrow or placenta-derived—best treat T2DM. In addition, they recommend that post-transplantation patients need close monitoring for the development of neoplasia as stem cells—whether multipotent or pluripotent—both have the potential for malignant transformation.

The study concluded that "autologous bone marrow-derived stem cell therapy in patients with T2DM results in significant decrease in insulin dose requirement."

Citation: Bhansali, A.; Asokumra,P.; Walia, R.; Bhansali, S.; Gupta, V.; Jain, A.; Sachdeva, N.; Sharma, R. R.; Marwaha, N.; Khandelwal, N. Efficacy and Safety of Autologous Bone Marrow Derived Stem Cell Transplantation in patients with Type 2 Diabetes mellitus: A randomized placebo-controlled study. Cell Transplantation.

Original press release: http://www.eurekalert.org/pub_releases/2013-06/ctco-t2d062813.php