Welcome to The Visible Embryo

Home-- -History-- -Bibliography- -Pregnancy Timeline- --Prescription Drugs in Pregnancy- -- Pregnancy Calculator- --Female Reproductive System- -Contact
 

Welcome to The Visible Embryo, a comprehensive educational resource on human development from conception to birth.

The Visible Embryo provides visual references for changes in fetal development throughout pregnancy and can be navigated via fetal development or maternal changes.

The National Institutes of Child Health and Human Development awarded Phase I and Phase II Small Business Innovative Research Grants to develop The Visible Embryo. Initally designed to evaluate the internet as a teaching tool for first year medical students, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than one million visitors each month.

Today, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than 1 million visitors each month. The field of early embryology has grown to include the identification of the stem cell as not only critical to organogenesis in the embryo, but equally critical to organ function and repair in the adult human. The identification and understanding of genetic malfunction, inflammatory responses, and the progression in chronic disease, begins with a grounding in primary cellular and systemic functions manifested in the study of the early embryo.

WHO International Clinical Trials Registry Platform


The World Health Organization (WHO) has created a new Web site to help researchers, doctors and
patients obtain reliable information on high-quality clinical trials. Now you can go to one website and search all registers to identify clinical trial research underway around the world!



Home

History

Bibliography

Pregnancy Timeline

Prescription Drug Effects on Pregnancy

Pregnancy Calculator

Female Reproductive System

Contact The Visible Embryo

News Alerts Archive

Disclaimer: The Visible Embryo web site is provided for your general information only. The information contained on this site should not be treated as a substitute for medical, legal or other professional advice. Neither is The Visible Embryo responsible or liable for the contents of any websites of third parties which are listed on this site.
Content protected under a Creative Commons License.

No dirivative works may be made or used for commercial purposes.

Return To Top Of Page
Pregnancy Timeline by SemestersFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresFemale Reproductive SystemEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterSecond TrimesterFirst TrimesterFertilizationDevelopmental Timeline
CLICK ON weeks 0 - 40 and follow along every 2 weeks of fetal development
Google Search artcles published since 2007
 
 

Home | Pregnancy Timeline | News Alerts | News Archive July 2, 2013

 
RORA has the potential to be under regulation by androgen and estrogen,
suggesting that RORA may also contribute to the male bias
towards autism spectrum disorder.






WHO Child Growth Charts

 

 

 

Research discovers autism gene regulates six other genes

A new study reports that RORA, a new candidate gene for autism discovered in 2010 by the same lab, regulates at least six other genes associated with autism.

“We are focusing on this gene, in part, because this gene can act as a master regulator of other genes,” said Valerie Hu, PhD. “Called nuclear hormone receptors, they are capable of activating or suppressing other genes in the genome. The question was which specific genes are regulated by RORA.” Dr. Hu is professor of biochemistry and molecular medicine at the George Washington University (GW) School of Medicine and Health Sciences (SMHS)


Hu and co-author, Tewarit Sarachana, Ph.D., found that RORA encodes a protein that can regulate the expression of more than 2,500 other genes. Of these 2,500 genes, many are known to be involved in neuronal development and functions, and 426 of RORA’s gene targets are already listed in AutismKB, a database of known autism candidate genes.


The genome-wide ChIP-on-chip analysis of  RORA target genes, confirmed that RORA transcriptionally regulates the genes: A2BP1, CYP19A1, HSD17B10, ITPR1, NLGN1, and NTRK2. When RORA levels were cut in half, all six genes also reduced their expression. The same reduced expression levels of these six genes is found in brain tissues from individuals with autism relative to that of unaffected individuals matched by age.

“We see it as a domino effect, where RORA is a particularly shaky domino,” said Hu. “If knocked over, it can also knock down a whole bunch of other genes, except that it’s not just a single chain of events. There are multiple chains of events, leading to massive disruption of gene expression in autism.”


A 2011 study by Hu’s group revealed that RORA has the potential to be under regulation by the hormones androgen and estrogen, suggesting that RORA may also contribute to the male bias towards autism spectrum disorder.


The new study is available online in the journal Molecular Autism.

About the GW School of Medicine and Health Sciences
Founded in 1825, the GW School of Medicine and Health Sciences (SMHS) was the first medical school in the nation’s capital and is the 11th oldest in the country. Working together in our nation’s capital, with integrity and resolve, the GW SMHS is committed to improving the health and well-being of our local, national and global communities. www.smhs.gwu.edu.

Original press release:http://smhs.gwu.edu/news/gw-researcher-discovers-new-regulatory-autism-gene