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Pregnancy Timeline by SemestersFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresFemale Reproductive SystemEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterSecond TrimesterFirst TrimesterFertilizationDevelopmental Timeline
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Home | Pregnancy Timeline | News Alerts | News Archive July 8, 2013

 
The study included a total of 43 different ethnic groups, the largest being Pakistani (45%)
and White British (just under 40%). In the Pakistani subgroup, 77% of babies born with
birth defects were to parents who were married blood relatives. In the White British
subgroup19% of babies with an anomaly were born to mothers over the age of 34.






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Key factors in rates of birth defects identified

New research highlights factors that can increase the chances of a baby being born with a birth defect.

It has been known for some time in the UK that birth defects, or congenital anomalies, are a major cause of infant death which varies across ethnic groups. Studies in the last 20 years considered marriage to a blood relative (consanguinity), as a cause of birth defects, but these studies didn't address other risk factors such as lower economic status (deprivation).

The work is published in The Lancet.


Findings from researchers at the Universities of Bradford and Leeds, funded by the National Institute for Health Research (NIHR), confirm that the two main factors associated with increased risk of birth defects are (1) being born to an older mother or (2) being born to parents who are blood relations.

In addition, the research also confirmed that socio-economic status (levels of deprivation) had no effect on the relative risk of birth defects, despite two-thirds of the mothers participating in the study coming from the most deprived fifth of the British population.

Results also showed that higher levels of maternal education halved the risk of having a baby with a defect across all ethnic groups.


Geneticist and lead author Dr Eamonn Sheridan, from the University of Leeds, says: "It is important to note that the vast majority of babies born to couples who are blood relatives are absolutely fine, and while consanguineous marriage increases the risk of birth defect from 3% to 6%, this risk is still small."

The study, funded by the NIHR Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for Leeds, York and Bradford, and the largest of its type ever conducted, examined detailed information collected about more than 11,300 babies involved in the Born in Bradford (BiB) project, a unique long term study which is following the health of babies who were born in the city at the Bradford Royal Infirmary between 2007 and 2011.

The research team found that the overall rate of birth defects in the BiB babies was approximately 3% - nearly double the national rate.

Each year, approximately 1.7% of babies in England and Wales are born with a birth defect such as heart or lung problems, or Down's Syndrome, which may be life-limiting. These disorders occur as a result of complex interactions between genetic and environmental factors, or because of damage from infections such as rubella and cytomegalovirus.

While the BiB cohort includes a total of 43 different ethnic groups, the largest ethnic groups were Pakistani (45%) and White British (just under 40%).

In the Pakistani subgroup, 77% of babies born with birth defects were to parents who were in consanguineous marriages. In the White British subgroup 19% of babies with an anomaly were born to mothers over the age of 34. Links between the age of mothers and the prevalence of birth defects are already well-established.

It is estimated that more than a billion people worldwide live in in communities where consanguineous marriage is commonplace.


The Bradford/Leeds study is the first to explore potential causes of birth defects in a population where there are enough numbers in both consanguineous (marriage to a blood relation) and non-consanguineous groups to generate statistically significant conclusions.


Professor Neil Small, co-author of the study from the University of Bradford, says: "The research is of particular importance to Bradford, because half the babies born in the city's one maternity hospital have a parent whose family origin is Pakistan. But the findings also are relevant across the world in countries where consanguineous marriage is a cultural norm.

In Bradford, there are initiatives that seek to raise community awareness and services such as genetic counselling and testing accessible to couples who are married or considering marriage to a blood relative. It is not our intention to counsel couples about who they choose to marry. But we do want to ensure couples are aware of any risks, so they can make informed choices when planning their families."

University of Bradford
Founded in 1966, the University of Bradford is one of the UK's 'traditional' universities. It is a research-active institution, with over 80 per cent of our research being rated as either 'international' or 'world-leading' in the 2008 Research Assessment Exercise (RAE). The University was ranked No 1 for Graduate Employment in the North of England and placed within the top ten in the UK by the Sunday Times University Guide 2013.

Known for its strong emphasis on employability skills and knowledge transfer work with businesses, the University has a truly global make up with over 20 per cent of its student population being international. The University is also a leader in sustainable development and education, and is within the top ten greenest universities in the UK, according to the Green League 2013.

National Institute for Health Research
The National Institute for Health Research (NIHR) is funded by the Department of Health to improve the health and wealth of the nation through research. Since its establishment in April 2006, the NIHR has transformed research in the NHS. It has increased the volume of applied health research for the benefit of patients and the public, driven faster translation of basic science discoveries into tangible benefits for patients and the economy, and developed and supported the people who conduct and contribute to applied health research. The NIHR plays a key role in the Government's strategy for economic growth, attracting investment by the life-sciences industries through its world-class infrastructure for health research. Together, the NIHR people, programmes, centres of excellence and systems represent the most integrated health research system in the world. For further information, visit the NIHR website.

This particular Born in Bradford project was supported by the NIHR Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for Leeds, York and Bradford. The views expressed in this news release are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.

Original press release:http://www.eurekalert.org/pub_releases/2013-07/uol-kfi070313.php