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Welcome to The Visible Embryo, a comprehensive educational resource on human development from conception to birth.

The Visible Embryo provides visual references for changes in fetal development throughout pregnancy and can be navigated via fetal development or maternal changes.

The National Institutes of Child Health and Human Development awarded Phase I and Phase II Small Business Innovative Research Grants to develop The Visible Embryo. Initally designed to evaluate the internet as a teaching tool for first year medical students, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than ' million visitors each month.


WHO International Clinical Trials Registry Platform
The World Health Organization (WHO) has created a new Web site to help researchers, doctors and patients obtain reliable information on high-quality clinical trials. Now you can go to one website and search all registers to identify clinical trial research underway around the world!



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Disclaimer: The Visible Embryo web site is provided for your general information only. The information contained on this site should not be treated as a substitute for medical, legal or other professional advice. Neither is The Visible Embryo responsible or liable for the contents of any websites of third parties which are listed on this site.
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Pregnancy Timeline by SemestersFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresFemale Reproductive SystemEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterSecond TrimesterFirst TrimesterFertilizationDevelopmental Timeline
Click weeks 0 - 40 and follow fetal growth
Google Search artcles published since 2007
 
August 5, 2011--------News Archive

Prenatal Stress Linked with Accelerated Cell Aging
Research points to critical role of maternal health and well-being during pregnancy.

Mutation Linked With the Absence of Fingerprints
Rare genetic mutations prove useful as a tool for investigating unknown aspects of our biology.


August 4, 2011--------News Archive

Pregnancy Diet Decreases Baby's Breast Cancer Risk
Era of Hope conference to feature compelling research examining benefits to daughters based on mother's diet in pregnancy.

Quick, Low-Cost Tests For Child Development Delays
Study confirms accuracy of developmental screening tests that can be administered by family physicians.


August 3, 2011--------News Archive

Helping Children Learn to Understand Numbers
It's all in the way we speak to them.

Pilot Study Suggests New Approach for Preeclampsia
Apheresis-based treatment may prolong pregnancy.

The Dark Side of Oxytocin
The "cuddle chemical" can also stir emotions like envy and gloating.


August 2, 2011--------News Archive

New Light on the Mechanisms of Brain Development
Study has implications for understanding brain disorders rooted in development, such as autism.

Why Autistic Individuals Confuse Pronouns
Impaired communication between areas of the brain causes autism and disrupts concept of 'self'.


August 1, 2011--------News Archive

Fast Ripples Mark Brain Seizure Activity in Children
Resection surgery of brain regions with fast ripples may improve seizure outcome.

Caloric Restriction and Female Infertility
Scientists tested the effects of caloric restriction on eggs produced by aging mice, and found they were better quality than age-matched mice fed a normal diet.

70 Percent of 8-Month-Old Babies Eat Too Much Salt
Due to being fed salty and processed foods like yeast extract, gravy, baked beans and tinned spaghetti, United Kingdom infants have too much salt in their bodies.

WHO Child Growth Charts


Reeler mice lack the reelin protein which reflects in their abnormal gait.

Scientists at the Allen Institute for Brain Science have taken an important step in identifying how the brain organizes itself during development.

The findings, published in the Journal of Comparative Neurology, describe – in more detail than ever before – the consequences of the loss of this key molecule needed in establishing proper brain architecture during brain development.

The study questions the current textbook explanation of abnormal brain development. Using a well-studied strain of mouse known as reeler, named for its abnormal "reeling" gait, an integral understanding has grown of how neurons migrate to their correct locations during brain development.

The reeler cortex has been described for many years as being "inverted" compared to a normal neocortex. However, the new research finds that this abnormal layering is far more complex, more closely resembling a mirror-image inversion of normal cortical layering.

Furthermore, the degree of disorganization is different for different cell types in different parts of the brain. This suggests that the correct patterning of the brain involves a complex set of processes selected by specific cell types.

This study combines high-throughput histology with highly specific cell markers (identifying genes with expression patterns in the Allen Mouse Brain Atlas), compared to a genome-wide map of gene expression of the adult mouse brain. The authors used a novel approach to identify features of cortical disorganization in the male reeler mouse that were unidentifiable with less specific methods previously available.

"To our surprise, we observed unexpected cellular patterning that is difficult to explain by current models of neocortical development," said Ed Lein, Senior Director, Neuroscience at the Allen Institute for Brain Science and senior author of the study.

"These findings have major implications ... These patterns suggest that there are a number of additional mechanisms beyond Reelin involved in the proper migration of newly generated neurons to their correct locations, and that different cell types use different cues in that process."

The reeler mouse has a spontaneous mutation in a gene called Reelin that has been implicated in autism. Studies of these mice, which are deficient in Reelin, have revealed the involvement of Reelin and its signaling pathway in the organization of the central nervous system during development. Particularly noted was its function in cortical layering, where newly generated neurons migrate from their birthplace to their proper positions in the developing cortex.

In the normal cortex this process results in a highly ordered architecture with different neuronal cell types restricted to specific cortical layers. With Reelin deficiency as seen in reeler mice, the migration process of newly generated neurons into the cortex is highly disrupted.

Using a technique that allows for precise localization of specific genes, Lein and collaborators were able to follow developmental expression patterns through several stages to describe precise effects of Reelin deficiency in several brain areas during neurodevelopment in reeler mice.

Using vivid images of cortical lamination, the authors illustrate the precise disorganization that occurs in reeler neurodevelopment compared to wild type mice. The paper includes 25 compelling full-color, cellular-resolution images, one of which is featured on the journal's cover for this issue.

Other authors on the paper include Maureen Boyle, Amy Bernard, Carol Thompson, Lydia Ng, Andrew Boe, Marty Mortrud, Michael Hawrylycz and Allan Jones from the Allen Institute for Brain Science and Robert Hevner from the University of Washington, Seattle Children's Hospital Research Institute.

Citation
Boyle MP, Bernard A, Thompson CL, Ng L, Boe A, et al. (2011) Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. Journal of Comparative Neurology 519: 2061-89. doi: 10.1002/cne.22655

About the Allen Institute for Brain Science
The Allen Institute for Brain Science (www.alleninstitute.org) is an independent, 501(c)(3) nonprofit medical research organization dedicated to accelerating understanding of the human brain by fueling discovery for the broader scientific community. Through a product-focused approach, the Allen Institute generates innovative public resources used by researchers and organizations around the globe. Additionally, the Institute drives technological and analytical advances, thereby creating new knowledge and providing new ways to address questions about the brain in health and disease. Started with $100 million in seed money from philanthropist Paul G. Allen, the Institute is supported by a diversity of public and private funds. The Allen Institute's data and tools are publicly available online at www.brain-map.org.

Original article: http://www.eurekalert.org/pub_releases/2011-08/aifb-nab080111.php