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Welcome to The Visible Embryo, a comprehensive educational resource on human development from conception to birth.

The Visible Embryo provides visual references for changes in fetal development throughout pregnancy and can be navigated via fetal development or maternal changes.

The National Institutes of Child Health and Human Development awarded Phase I and Phase II Small Business Innovative Research Grants to develop The Visible Embryo. Initally designed to evaluate the internet as a teaching tool for first year medical students, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than ' million visitors each month.


WHO International Clinical Trials Registry Platform
The World Health Organization (WHO) has created a new Web site to help researchers, doctors and patients obtain reliable information on high-quality clinical trials. Now you can go to one website and search all registers to identify clinical trial research underway around the world!



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Disclaimer: The Visible Embryo web site is provided for your general information only. The information contained on this site should not be treated as a substitute for medical, legal or other professional advice. Neither is The Visible Embryo responsible or liable for the contents of any websites of third parties which are listed on this site.
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Pregnancy Timeline by SemestersFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresFemale Reproductive SystemEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterSecond TrimesterFirst TrimesterFertilizationDevelopmental Timeline
Click weeks 0 - 40 and follow fetal growth
Google Search artcles published since 2007
 
August 5, 2011--------News Archive

Prenatal Stress Linked with Accelerated Cell Aging
Research points to critical role of maternal health and well-being during pregnancy.

Mutation Linked With the Absence of Fingerprints
Rare genetic mutations prove useful as a tool for investigating unknown aspects of our biology.


August 4, 2011--------News Archive

Pregnancy Diet Decreases Baby's Breast Cancer Risk
Era of Hope conference to feature compelling research examining benefits to daughters based on mother's diet in pregnancy.

Quick, Low-Cost Tests For Child Development Delays
Study confirms accuracy of developmental screening tests that can be administered by family physicians.


August 3, 2011--------News Archive

Helping Children Learn to Understand Numbers
It's all in the way we speak to them.

Pilot Study Suggests New Approach for Preeclampsia
Apheresis-based treatment may prolong pregnancy.

The Dark Side of Oxytocin
The "cuddle chemical" can also stir emotions like envy and gloating.


August 2, 2011--------News Archive

New Light on the Mechanisms of Brain Development
Study has implications for understanding brain disorders rooted in development, such as autism.

Why Autistic Individuals Confuse Pronouns
Impaired communication between areas of the brain causes autism and disrupts concept of 'self'.


August 1, 2011--------News Archive

Fast Ripples Mark Brain Seizure Activity in Children
Resection surgery of brain regions with fast ripples may improve seizure outcome.

Caloric Restriction and Female Infertility
Scientists tested the effects of caloric restriction on eggs produced by aging mice, and found they were better quality than age-matched mice fed a normal diet.

70 Percent of 8-Month-Old Babies Eat Too Much Salt
Due to being fed salty and processed foods like yeast extract, gravy, baked beans and tinned spaghetti, United Kingdom infants have too much salt in their bodies.

WHO Child Growth Charts


A technology reducing elevated levels of Flt-1 protein in the blood of women with preeclampsia, may become a therapy treating the life-threatening condition.

In a paper receiving online release in the journal Circulation, a team of U.S. and German researchers report promising results from a filtration technology that reduces excess levels of soluble Flt-1, a protein in blood that limits the growth of blood vessels, in women with very preterm preeclampsia.

"Introducing new therapies in pregnancy is uncommon because of the need to avoid extra risks to both the mother and baby," says Ravi Thadhani, MD, MPH, of the Massachusetts General Hospital (MGH) Division of Nephrology, co-corresponding author of the report.

"In this paper we show that a disease that affects thousands of women around the world may one day be able to be managed by the therapy we developed. This was a small, proof-of-concept study to see if the therapy is safe and possibly effective; so larger, randomized trials now need to be done."

Affecting 5 to 7 percent of pregnancies, preeclampsia is characterized by high blood pressure, protein in the urine and additional metabolic abnormalities. If symptoms progress, it can lead to kidney or liver failure, brain swelling, seizures and death.

Since the only way to halt the process is to deliver the fetus, the earlier in a pregnancy preeclampsia occurs the greater the risk to the baby. Very preterm delivery – before 32 weeks of gestation – has been estimated to increase infant mortality as much as 70 times over full-term delivery at 37 or more weeks. Very preterm babies who do survive may face lifelong complications such as cerebral palsy, so finding an intervention that can safely prolong pregnancy is vitally important.

The underlying cause of preeclampsia is still unknown, but one hypothesis is that factors released into the bloodstream by the placenta damage blood vessels throughout the body.

In a 2003 study Ananth Karumanchi, MBBS, of the Beth Israel-Deaconess Medical Center, a co-author of the current study, identified soluble Flt-1 as a possible factor in preeclampsia.

Released by the placenta and other tissues, soluble Flt-1 blocks the vascular growth factor VEGF which is essential to maintaining healthy blood vessels. However, levels of soluble Flt-1 are extremely elevated in women with very preterm preeclampsia. Developing a preeclampsia treatment based on removing a factor like soluble Flt-1 rather than administering drugs that may have side effects, presents an attractive strategy.

Thadhani and his colleagues adapted the blood-filtering technologies used in apheresis to develop a method of rapidly removing soluble Flt-1 from the bloodstream. Since a blood test to measure soluble Flt-1 levels is available in Germany, Thadhani collaborated with researchers at the University of Cologne and the University Hospital Leipzig, for the pilot clinical study.

The first phase was designed to confirm the safety of the treatment. In five patients with very preterm preeclampsia and elevated soluble Flt-1, levels dropped after a single treatment, greater decreases followed with longer treatment. There were no major side effects, but because the treatment sessions were brief, no extension of pregnancy was expected or seen.

The researchers then offered three women with very preterm preeclampsia – from 27 to 30 weeks – the opportunity to receive several treatment sessions in an attempt to extend their pregnancies. Two patients, one of them carrying twins, received two treatments; and the third received four. After each treatment session, the patients' soluble Flt-1 levels dropped from 20 to 30 percent for several days along with urinary protein levels.

Various factors, including recurrence of preeclampsia symptoms, eventually required premature delivery of all babies; but the pregnancies had been maintained from two to three weeks following hospital admission. A control group of patients receiving standard preeclampsia monitoring required delivery an average of 3.6 days following hospital admission. While the babies of women receiving the novel treatment needed the type of support typically required for premature infants, they all were discharged from the hospital with few complications.

"There has never been an effective therapy for this condition," says Thadhani, an associate professor of Medicine at Harvard Medical School.

"We've been working for over a decade to find ways to extend the baby's time in utero while preventing the rapid acceleration of preeclampsia that can take a mother from feeling fine to a coma in a matter of hours. One of the beauties of an approach based on removing something instead of giving a drug is that it can be carefully controlled and, if necessary, quickly turned off. While this study is too small to allow us to say that our treatment was responsible for extending these patients' pregnancies – that will require a larger, randomized clinical trial – this first step holds promise."

Support for the study included grants from the Discovery Fund of the MGH Department of Medicine, and from the University of Cologne and Howard Hughes Medical Institute.

Thadhani and co-author Karumanchi hold patents related to preeclampsia prediction and the use of angiogenic proteins in preeclampsia, respectively. Additional co-authors of the Circulation paper are Tuelay Kisner, MD, Henning Hagmann, MD, Verena Bossung, MD, Stefanie Noack, RN, Peter Mallmann, MD, Angela Kribs, MD, and Oliver Cornely, MD, University of Cologne; Wiebke Schaarschmidt, MD, Alexander Jank, MD, Clauria Kreyssig, MD, and Tom Lindner, MD, University Hospital Leipzig; Linda Hemphill, MD, MGH Division of Nephrology; and Alan Rigby, PhD, and Santosh Khedhar, PhD, Beth Israel-Deaconess Hospital.

Celebrating the 200th anniversary of its founding in 1811, Massachusetts General Hospital (www.massgeneral.org) is the original and largest teaching hospital of Harvard Medical School.