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Welcome to The Visible Embryo, a comprehensive educational resource on human development from conception to birth.

The Visible Embryo provides visual references for changes in fetal development throughout pregnancy and can be navigated via fetal development or maternal changes.

The National Institutes of Child Health and Human Development awarded Phase I and Phase II Small Business Innovative Research Grants to develop The Visible Embryo. Initally designed to evaluate the internet as a teaching tool for first year medical students, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than ' million visitors each month.


WHO International Clinical Trials Registry Platform
The World Health Organization (WHO) has created a new Web site to help researchers, doctors and patients obtain reliable information on high-quality clinical trials. Now you can go to one website and search all registers to identify clinical trial research underway around the world!



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Disclaimer: The Visible Embryo web site is provided for your general information only. The information contained on this site should not be treated as a substitute for medical, legal or other professional advice. Neither is The Visible Embryo responsible or liable for the contents of any websites of third parties which are listed on this site.
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Pregnancy Timeline by SemestersFemale Reproductive SystemFertilizationThe Appearance of SomitesFirst TrimesterSecond TrimesterThird TrimesterFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterDevelopmental Timeline
Click weeks 0 - 40 and follow fetal growth
Google Search artcles published since 2007
 
November 4, 2011--------News Archive

Identifying Brain Cells That Keep Us Awake
Researchers at UCLA have identified the group of neurons that mediates whether light arouses us — or not.

TBL1X Gene Involved In Autism Spectrum Disorder
An X-chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males.

“Love Hormone” Helps Direct Development of Brain
Hormones released from nerves regulate a series of vital body processes, including the balance of fluids and uterine contractions in childbirth.

November 3, 2011--------News Archive

Steroids in Preemies Impair Brain Growth
Premature infants given drugs to support lung maturation and normalize blood pressure, are at increased risk for having impaired growth of the cerebellum.

Potential Treatment for Sickle Cell Disease
Increasing the expression of proteins TR2/TR4 can lead to higher fetal hemoglobin levels in sickle cell patients.

New Drug Shows Promise Against Multiple Sclerosis
A new drug targets a molecule - CD20 found on the surface of B cells and B cells seem to induce the immune system T cells to attack.

November 2, 2011--------News Archive

Babies Understand Each Other at Ten Months Old
At 10 months, babies start to understand another person’s thought process, providing new insights on how communication develops.

Bacteria Swap Genes Between Species Readily
Microbes have developed a quick and effective way to exchange genetic information from animals to humans.

Pinpointing Cause of Unexplained Miscarriage
The same kind of blood-clotting in coronary arteries or blood vessels in the brain which causes heart attacks and strokes also happens in the placenta.

November 1, 2011--------News Archive

Pregnant Mothers At Risk From Air Pollution
A Californian-based study has looked in detail at air quality and the impact of traffic-related air pollution on premature birth.

Linking A Spectrum of Childhood Diseases
An international collaboration of scientists has identified a genetic mutation causing a rare childhood disease characterized by inflammation and fat loss.

Placenta and Uterus Battle Becomes Preeclampsia
A battle brews in the mother’s womb between the father’s biological goal to produce the biggest, healthiest baby possible vs. the mother’s need to live through delivery.

October 31, 2011--------News Archive

Fetal Heart Rate Not a Good Indicator for Health
Maternal-fetal medicine specialists at Intermountain Medical Center seek better 'road map' to improve deliveries, healthier babies.

Swedish Discover Bisphenol A Affects Newborn Brain
An observed effect induced in neonatal baby mice after exposure to Bisphenol A, persisted into adulthood.

Not Your Mother's Birth Control
Today's hormonal forms of birth control are vastly different from those used by earlier generations of women, both with lower levels of hormones and with different means of delivery (not just a pill), but many of the same problems related to women's pleasure remain.

WHO Child Growth Charts

A University of Michigan Health System laboratory study reveals a key trigger for producing normal red blood cells that could lead to a new treatment for those with sickle cell disease.

The study, conducted in mice, appears in this week's early edition of the Proceedings of the National Academy of Sciences, and holds promise for preventing the painful episodes and organ damage that are common complications of sickle cell disease.

According to the U-M study, increasing the expression of the proteins, TR2 and TR4, more than doubled the level of fetal hemoglobin produced in sickle cell mice and reduced organ damage.

It's the first time specific proteins have been targeted to prevent a disease, authors say.

"The vast majority of sickle cell disease patients are diagnosed early in childhood when adult hemoglobin normally replaces fetal hemoglobin, but the severity of the disease can differ markedly, correlating most strongly with the level of fetal hemoglobin present in red cells," says pediatrician and lead study author Andrew D. Campbell, M.D., director of the Pediatric Comprehensive Sickle Cell Program at the U-M Cancer Center.

Sickle cell is an inherited blood disorder impacting hundreds of thousands of patients worldwide that causes normal red blood cells to change shape to a crescent moon.

The result is life-long debilitating pain episodes, chronic organ damage and significantly shortened life span. But a small number of sickle cell patients are born with a high enough fetal hemoglobin level to moderate these complications.

The study team, that included pediatric hematologists, cell and developmental biologists and pathology experts at U-M and the University of Tsukuba, Japan, demonstrated a potential method for boosting the fetal hemoglobin levels by modulating TR2/TR4 expression.

"While the average fetal hemoglobin was 7.6 percent in the sickle cell mice, the TR2/TR4 treated sickle cell mice had an average fetal hemoglobin of 18.6 percent," says senior study author James Douglas Engel, Ph.D. , professor and chair of the U-M's Cell and Development Biology Department.

He adds that anemia and red blood cell turnover all improved within the TR2/TR4 mice. Additional studies, including clinical trials, would be requiredto determine if the technique could help humans.

"Currently hydroxyurea is the only FDA approved drug known to increase the levels of fetal hemoglobin within sickle cell disease patients and a substantial number of patients do respond to it," says Campbell, the pediatric hematology oncology specialist.

"But the long term consequences for hydroxyurea are unknown, especially in children."

Authors: Andrew D. Campbell, Shuaiying Cui, Lihong Shi, Rebekah Urbonya, Andrea Mathias, Kori Bradley, Kwaku O. Bonsua, Rhonda R. Douglas, Brittne Halford, Lindsay Schmidt, David Harro, Donald Giacherio, Keiji Tanimoto, Osamu Tanabe, and James Douglas Engel.

Reference: "Forced TR2/TR4 Expression in Sickle Cell Disease Mice Confers Enhanced Fetal Hemoglobin Synthesis and Alleviated Disease Phenotypes," Proceedings of the National Academy of Sciences, Oct. 31, 2011.

Funding: Authors work was supported by the American Heart Association, Cooley's Anemia Foundation, Robert Wood Johnson Foundation and the National Institutes of Health's National Heart Lung and Blood Institute.

Original article: http://www.uofmhealth.org/news/protein-trigger-sickle-cell-disease