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Welcome to The Visible Embryo, a comprehensive educational resource on human development from conception to birth.

The Visible Embryo provides visual references for changes in fetal development throughout pregnancy and can be navigated via fetal development or maternal changes.

The National Institutes of Child Health and Human Development awarded Phase I and Phase II Small Business Innovative Research Grants to develop The Visible Embryo. Initally designed to evaluate the internet as a teaching tool for first year medical students, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than ' million visitors each month.


WHO International Clinical Trials Registry Platform
The World Health Organization (WHO) has created a new Web site to help researchers, doctors and patients obtain reliable information on high-quality clinical trials. Now you can go to one website and search all registers to identify clinical trial research underway around the world!



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Disclaimer: The Visible Embryo web site is provided for your general information only. The information contained on this site should not be treated as a substitute for medical, legal or other professional advice. Neither is The Visible Embryo responsible or liable for the contents of any websites of third parties which are listed on this site.
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Pregnancy Timeline by SemestersFemale Reproductive SystemFertilizationThe Appearance of SomitesFirst TrimesterSecond TrimesterThird TrimesterFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterDevelopmental Timeline
Click weeks 0 - 40 and follow fetal growth
Google Search artcles published since 2007
 
December 2, 2011--------News Archive

Working Moms Multitask More Than Dads
Not only are working mothers multitasking more frequently than working fathers, but their multitasking experience is more negative as well.

Unlocking the Genetic Mystery of Sarcomas
Study uncovers potential targets for treating a disease affecting children and adults.

When Babies Wake, Cortisol Rises to Mom's Level
The hormone cortisol in adults rises and lowers according to stress. But in babies cortisol remains level following waking - and tunes in with mom's level.

December 1, 2011--------News Archive

Home Births – Then and Now
A comparison of home-birth trends of the 1970s finds many similarities – and some differences – related to trends in home births today.

Risk of Suicide In Pregnant Women, New Mothers
An analysis of new data highlights risk factors that could be targeted by interventions.

Addiction Damages PreFrontal Cortex
Brain structure-function impairment may be related to an inability to assess rewards and consequences, behavior associated with addiction.

November 30, 2011--------News Archive

Gene Puts Brakes On Breast Cancer Progression
Newly published research explores the role of gene in tumour suppression

‘Perfect Parent’ Not A Good Idea
Seeking perfection as a parent works better for dads than for moms.

Kindergarten Friendships Matter, Especially for Boys
High-quality friendships in kindergarten may mean that boys will have fewer behavior problems and better social skills in first and third grades.

November 29, 2011--------News Archive

Cleft Lip Corrected Genetically in Mouse Model
Scientists have successfully genetically repaired cleft lips in mice embryos specially engineered for the study of cleft lip and cleft palate.

Common Herbicide Creates Reproductive Problems
International researchers link exposure to atrazine – an herbicide widely used in the U.S. and more than 60 other nations – to reproductive problems in animals.

Environment and Diet Leave Imprints On the Heart
DNA methylation in the human heart has revealed the 'missing link' between lifestyle and health, and may indicate methylation creates the equivalent of 5, 6, 7 and 8 bases by modifying Cytosines across our entire genome.

November 28, 2011--------News Archive

Role of Nuclear Membrane Protein in Organ Growth
Scientists had thought B-type lamin proteins were vital to embryonic stem cells; but they are more critical to organ formation.

Hormone Hepcidin May Control Atherosclerosis
Hepcidin is a hormone produced by the liver and regulates iron transport. Blocking its production encourages macrophages to counter atherosclerosis.

Two Enzymes Stamp DNA with "Turn Off" Signal
Inside the cell nucleus, DNA is wound around spool-like proteins called histones. Two modifications in this attachment tell a portion of the DNA to be on or off.

WHO Child Growth Charts


Hepcidin is a hormone produced by the liver that regulates iron transport. Blocking its production encourages macrophages to act in "detox mode," countering atherosclerosis.

Researchers at Emory University School of Medicine have identified hepcidin, a hormone that regulates iron levels in the body, as a potential target for treating atherosclerosis.

Suppressing hepcidin is a way to reduce the iron levels inside the white blood cells found in arterial plaques. Reducing iron levels pushes those cells to clean up harmful cholesterol in a process called “reverse cholesterol transport,” interfering with atherosclerosis, researchers have found.

The data was presented Wednesday, Nov. 16 by Aloke Finn, MD, assistant professor of medicine (cardiology) and colleague Omar Saeed at the American Heart Association Scientific Sessions meeting in Orlando. Charles Hong, MD, PhD, from Vanderbilt University and collaborators from CVPath Institute contributed to the research.

Update: The results were published online in the American Heart Association journal ATVB (Arteriosclerosis, Thrombosis and Vascular Biology) on Nov. 17.

When mice modeling atherosclerosis are given a compound that reduces hepcidin levels, they have smaller atherosclerotic plaques and less fat in their plaques, as well as reduced foam cell formation. Foam cells are macrophages (white blood cells) that accumulate cholesterol and are signs of atherosclerosis.

The compound LDN 193189 reduces hepcidin levels by blocking its production. LDN 193189 is also being investigated as a treatment for inflammatory bowel disease and for anemia related to critical illness.

In the ATVB paper, the authors caution that therapies that reduce hepcidin need to be evaluated for whether they result in hemochromatosis (iron overload): "Although multiple mechanisms exist within humans to counteract iron-related toxicity..., it remains possible that such toxicity could be a limitation to the actual clinical adoption of such a strategy."

At the meeting, Finn also presented research on how hemoglobin, the iron-containing protein that allows red blood cells to carry oxygen, affects macrophages. He and his colleagues used isolated human cells and a rabbit model of atherosclerosis to show that macrophages respond to hemoglobin by increasing production of proteins that transport cholesterol and pump iron out.

In the context of atherosclerosis, iron is toxic because it amplifies the action of reactive oxygen species, leading to more inflammation and more foam cells. Previous research has shown that hemorrhage within atherosclerotic plaques, leading to the release of hemoglobin from red blood cells, is linked to enlargement of the plaque’s necrotic core – a sign of “vulnerable plaque.”

“We were led to the hepcidin research by our work on macrophages,” Finn says. “We discovered a different type of macrophages that detoxify iron. They take it up and spit it out again with ferroportin, an iron transport protein.”

“Hemorrhage is bad, but as bad at it is, these macrophages seem to protect against the toxic effects of iron. Giving macrophages hemoglobin encourages them to behave in this detox mode,” he says.

This study was supported by the Carlyle Fraser Heart Center, CVPath Inc., and the National Institutes of Health. It is possible that Finn and Emory could benefit financially from this technology’s future commercialization.

The Robert W. Woodruff Health Sciences Center of Emory University is an academic health science and service center focused on missions of teaching, research, health care and public service.

Original article:http://shared.web.emory.edu/whsc/news/releases/2011/11/hormone-that-controls-iron-levels-may-be-target-for-atherosclerosis-treatment.html