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Home | Pregnancy Timeline | News Alerts |News Archive Nov 27, 2014
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Mom's presence changes genes in infant brain A mother's tender loving care, her "TLC", can not only help soothe infants in pain, but may actually impact early brain development by altering gene activity in the amygdala. According to research led by New York University (NYU), Langone Medical Center, a loving mother's touch can create positive effects on a developing brain.By carefully analyzing infant rat brains, NYU researchers found that several hundred genes became active when pups experienced a painful stimulus. However, with their mothers present, fewer than 100 genes were similarly expressed in pups' brains under the same stimulus. According to Regina Sullivan PhD, senior investigator and neurobiologist who led the research, this is the first time that short-term affects of maternal caregiving have been reflected in a distressed pup's brain. The study was designed to reflect the long-term consequences of maternal nuturing in mammals — beginning with birth.
Dr. Sullivan's work is published in Current Biology. Sullivan's previous research has revealed that a rat mother's physical presence affects the electrical signals being sent through an infant pup's brain. With this research, her analysis of gene changes in amygdalas of infant rats — a brain region responsible for processing fear, pain and pleasure — adds to the complexity of understanding how pain in newborns, whether rats or humans, affects the developing brain. "Nobody wants to see an infant suffer, in rats or any species," says Sullivan. "But, if opiates are too dangerous to use in human infants because of their addictive properties, the challenge remains to find alternatives — including maternal comfort, coddling, or cues such as a mother's scent, that might relieve infant pain and protect the developing brain."
Highlights Besides Sullivan, Gordon A. Barr, at the University of Pennsylvania, served as lead investigator for this study. Funding support for the study was provided by the US National Institute of Child Health and Human Development and the National Institute of Mental Health, both parts of the National Institutes of Health. Corresponding federal grant numbers are R01 DC009910 and R01 MH0901451. |