|Home- - -History-- -Bibliography- -Pregnancy Timeline- --Prescription Drugs in Pregnancy- -- Pregnancy Calculator- --Female Reproductive System- News Alerts -Contact|
Click weeks 0 - 40 and follow fetal growth
Steroid Increases Life Expectancy for Preemies
A New Understanding of How Our Lungs Grow
Early Pregnancy Stress, Pre-Term Birth, Fewer Boys
Mother's Touch Protects Child Against Drug Cravings
Flu Vaccine Protects Pregnant Mom and New-Borns
Tadpoles Made to Grow Eyes on Back and Tail
Baby See, Baby Do?
Bitter Taste of Broccoli Not Just About Flavor
Game Players Advance Genetic Research
One Quarter of Families Begin Before 24 Years Old
Orphans Undergo Biological Change to Their Genome
Child Abuse Changes the Brain
Defect in Brain May Cause Autism-Like Syndrome
Flipping Off the Switch that Causes Aging
Mapping the Neurons Created in Youth
The H1N1 flu vaccine protects both pregnant women and newly-borns
The researchers studied the immune response of 107 pregnant women after they were injected with a single dose of non-adjuvant H1N1 vaccine. They concluded that the influenza shot boosted the immune response in pregnant women and at the same time protected neuronatal babies via the antibodies that transferred through the placenta.
These results were published in the review Annals of Internal Medicine dated December 6th, 2011.
Influenza (the flu) is a contagious, acute respiratory infection caused by the family of viruses Influenzae. There are three types of Influenza virus: A, B and C. The A and B viruses cause seasonal (or winter) epidemics, but only the A virus is responsible for worldwide epidemics. Very soon into the worldwide influenza epidemic of 2009, pregnant women and neonatal babies were found to be at very high risk of complications and death if infected, as had already been observed during previous worldwide influenza epidemics. As early as August 2009, a study published in The Lancet showed that 10% of the serious cases were observed in pregnant women, whereas they represented only 1% of the total French population. So H1N1 influenza vaccination of pregnant women was recommended as a priority.
The team led by Odile Launey, the Director of vaccinology at the Centre for Clinical Investigation at Cochin Pasteur (Inserm/AP-HP/Institut Pasteur/Université Paris Descartes), carried out a vaccination study in order to demonstrate the immunogenicity, in other words the immune response in terms of the production of antibodies, after a single injection of a nonadjuvant A strain (H1N1) into women at 21 days and 42 days of gestation and to measure the transplacentary transfer of the mother's antibodies to neonatal babies.
This study concerned 107 women between 22 and 32 weeks of amenorrhea who were monitored in 5 French neonatal clinics between November 3rd and December 4th 2009 after being injected into the arm with an injection of H1N1 A strain vaccine.
Blood tests were carried out in order to measure the antibody counts protecting against the influenza virus:
Piror to vaccination
On delivery, a blood sample is taken from the umbilical cord in order to measure the quantity of influenza antibodies transmitted to the newly born. All events observed in mothers and babies during the study were recorded.
Prior to vaccination, 19% of the patients already presented H1N1 strain antibodies at levels considered to be protective. Three and six weeks after vaccination, 98% of the patients presented blood antibody counts considered to be protective. On delivery and 3 weeks after delivery, the proportion of patients with antibody counts considered to be protective were between 92% and 90%. The umbilical cord samples of newly born babies showed antibody counts considered to be protective in 95% of cases, some antibody concentrations were even higher than in the mothers (a ratio of 1.4 between neonatal babies concentrations and maternal concentrations at delivery).
"These results show that the influenza vaccine boosts the immune system in pregnant women and also protects newly-borns via transplacenta transfer ," concludes Odile Launay.
This study and an increasing number of other studies on pregnant women have confirmed the non-toxicity of the influenza vaccine during pregnancy. This year again, pregnant women are strongly recommended to take the influenza vaccine. The composition of the vaccine is modified each year to cover the major strains of the previous winter, which are the strains most likely to be present the next winter.
"The H1N1 2009 virus is still around. That's why the inactivated H1N1 virus is still present in the current seasonal influenza vaccine." So it is highly recommended to vaccinate pregnant women in order to protect them and their baby, because otherwise the vaccine cannot be administered to babies before the age of 6 months", explains Odile Launay.
The influenza vaccination campaign in Metropolitan France will run from September 29th 2011 to January 31st 2012. This year again, the public health authorities (HCSP) recommend vaccinating pregnant women from day 21 of pregnancy and also persons suffering from obesity (who have a body mass index of 30 or more)*. The Health Service covers 100% of the cost for all high-risk persons, including pregnant women from day 21 of their pregnancy.
*(Decision by the public health authorities on July 13th 2011 during talks on setting up the 2011-2012 influenza vaccination campaign - July 31st, 2011)
Maternal Immune Response and Neonatal Seroprotection to a Single Dose of a Monovalent Non adjuvanted 2009 Influenza A(H1N1) Vaccine A Single-Group Trial. VassilisTsatsaris, MD, PhD; Catherine Capitant, MD; Thomas Schmitz, MD; CorineChazallon, MSc; Sophie Bulifon, MD; Didier Riethmuller, MD, PhD; Olivier Picone, MD; Patrice Poulain, MD, PhD; Fanny Lewin, MD; FabriceLaine´ , MD; EvelyneJacqz-Aigrain, MD, PhD; Jean-Pierre Aboulker, MD; and OdileLaunay, MD, PhD for the Inserm C09-33 PREFLUVAC (Immunogenicity and Safety of an Inactivated NonadjuvantedA[H1N1v] Influenza Vaccine in Pregnant Women) Study Group*
Annals of Internal Medicine, 6 décembre 2011 http://www.annals.org/content/155/11/733.abstract
Original article: http://www.eurekalert.org/pub_releases/2011-12/ind-thf120711.php