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Welcome to The Visible Embryo, a comprehensive educational resource on human development from conception to birth.

The Visible Embryo provides visual references for changes in fetal development throughout pregnancy and can be navigated via fetal development or maternal changes.

The National Institutes of Child Health and Human Development awarded Phase I and Phase II Small Business Innovative Research Grants to develop The Visible Embryo. Initally designed to evaluate the internet as a teaching tool for first year medical students, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than ' million visitors each month.


WHO International Clinical Trials Registry Platform
The World Health Organization (WHO) has created a new Web site to help researchers, doctors and patients obtain reliable information on high-quality clinical trials. Now you can go to one website and search all registers to identify clinical trial research underway around the world!



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Pregnancy Timeline by SemestersFemale Reproductive SystemFertilizationThe Appearance of SomitesFirst TrimesterSecond TrimesterThird TrimesterFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterDevelopmental Timeline
Click weeks 0 - 40 and follow fetal growth
Google Search artcles published since 2007
 
December 16, 2011--------News Archive

Cancer and Fetal Exposure to Carcinogens
Some cancer, chronic diseasse and neurologic disorders can be attributed to fetal exposure to carcinogens as seen in studies of mice.

Gene Discovered for Weaver Syndrome
Research finds new gene for a rare genetic disorder; and also shows gene mutations in fetus cause syndromes- but same mutation later becomes cancer.

Mom's Asthma Inhaler Risks Child Endocrine Issues
Inhaled glucocorticoids for treating asthma in pregnancy are not associated with increased risk of most diseases in babies, but may increase baby's risk for endocrine and metabolic problems.

December 15, 2011--------News Archive

Progesterone Reduces Neonatal Risk
Women with a short cervix should be treated with vaginal progesterone to prevent preterm birth, according to a landmark study by leading obstetricians worldwide.

The Ability to Love Takes Root in Earliest Infancy
The first 12 to 18 months of life may predict your behavior in romantic relationships 20 years later.

Fetal Trachea Correction Increases Survival
A new study reveals that fetal tracheal occlusion (FETO) improves infant survival rate in severe cases of congenital diaphragmatic hernia (CDH).

December 14, 2011--------News Archive

Vaccine Successfully Attacks Breast Cancer in Mice!
Vaccine may have implications for treating ovarian, colorectal and pancreatic cancer.

Mom Weight Before/During Pregnancy Affects Baby
Both pre-pregnant weight and weight gain in pregnancy can predict babies’ birthweight. And high birthweight may also predict an overweight adult.

FoxC1 Gene Discovered to Maintain a Clear Cornea
Gene found in humans and mice that protects transparency of cornea, may lead to new therapy for some causes of blindness.

December 13, 2011--------News Archive

Animal Empathy, How Is It Different From Human?
Neuroscientist says animal models could open door to human feelings.

Clues to How the Pancreas Develops
A rare genetic disorder has given insight into how the pancreas develops. It may be possible to 'program' stem cells to become pancreatic cells.

Mitosis - Making The Right Copy At The Right Time
Scientists show how cells accurately inherit information gained epigenetically.

December 12, 2011--------News Archive

Gene Therapy Against Hereditary Bleeding Disorder
Gene therapy offers first proof that the treatment benefits adults with hemophilia B, reducing need for clotting factor to prevent bleeds.

What Goes On Behind Babies Gift of Gab
From the moment they're born, babies are highly attuned to communicate and motivated to interact. And they're great listeners.

Adult Brains Can Continue to Grow With Learning
London's taxi drivers' must pass a test showing they have memorized that city's complex layout of 25,000 streets – causing structural changes in their brains.

WHO Child Growth Charts

Some gene mutations occurring in fetal life, produce developmental problems such as Weaver (left) and Soto (right) syndromes. But, the same gene mutations occurring later in life produce cancer.


Scientists have found a gene that causes Weaver syndrome, a rare genetic disorder that typically causes large size at birth, tall stature, developmental delay during childhood, and intellectual disability. Published today in the American Journal of Human Genetics, the discovery means that testing the EZH2 gene for mutations could help families who are seeking a diagnosis for their child.

"For the families among whom we identified the gene, this discovery definitively brings the diagnostic odyssey to a close – it's DNA confirmation that their children have Weaver syndrome," says Dr. William Gibson, the study's lead investigator. Dr. Gibson is a clinician scientist at the Child & Family Research Institute at BC Children's Hospital and an assistant professor in the Department of Medical Genetics at the University of British Columbia (UBC).

"Our discovery enables DNA-based diagnostic testing for this particular disease," says Dr. Gibson. "For physicians who suspect Weaver syndrome in one of their patients, we can now confirm it if we find mutations in EZH2. There may still be other Weaver syndrome genes, and we need to study more families to be sure."

Presently, doctors diagnose Weaver syndrome by assessing a child's face, growth, skeleton and other clinical features. People with Weaver syndrome have an oversized head, typical facial features, problems with muscle tone and joints, and differences in the way their skeleton matures. Mutations in the NSD1 gene, which normally causes a rare disease called Sotos syndrome, are also known to cause Weaver syndrome in some cases. There may be other genes involved in Weaver syndrome that are yet to be discovered.

"Now we have an answer for these families and we are also in a position to provide answers to other families affected by this rare and difficult disease," says Dr. Gibson. Dr. Gibson is available to see new patients clinically for diagnosis of Weaver syndrome. As a result of this discovery, Dr. Gibson's team now offers sequencing of the EZH2 gene on a research basis in partnership with the Ottawa Hospital Research Institute. Dr. Gibson's team can be contacted by email at wtgibson@cfri.ubc.ca.

Traditionally, hunting for a disease-causing gene has relied on tracking a gene throughout a family's history. However, Weaver syndrome usually occurs only once in a family, as it is thought to be caused by a new genetic mutation in the sperm or egg that conceived the child. For this study, the investigators sought patients with Weaver syndrome from Canada and the United States. They approached Dr. David Weaver, who discovered the syndrome in 1974 and is professor emeritus of Medical and Molecular Genetics at Indiana University School of Medicine in Indianapolis.

In two families that Dr. Weaver had examined, the Canadian team looked for brand new genetic mutations by comparing the DNA of affected children to DNA from their unaffected parents. Once the investigators identified EZH2 as a candidate gene, they sequenced it in DNA samples from a third Canadian family. They confirmed that an EZH2 mutation was in this third family's child but not in either of her healthy parents.

EZH2 is a cancer gene that is known to be mutated in leukemia, B-cell lymphomas and some other blood cancers. The gene helps control how DNA is packaged around specific proteins, which in turn helps to regulate which groups of genes are turned off and on.

"Our finding illuminates an emerging area of biology that links developmental syndromes and cancer," says Dr. Gibson. "It appears that some mutations in EZH2, if these occur early in life, produce developmental syndromes such as Weaver syndrome, whereas mutations in the same gene that occur later in life can produce cancer."

Dr. Steven Jones is the study's senior author who led the DNA sequencing and bioinformatics. He is head of bioinformatics and associate director of the Michael Smith Genome Sciences Centre at BC Cancer Agency, professor in the UBC Department of Medical Genetics, and professor, Molecular Biology & Biochemistry at Simon Fraser University (SFU).

This research evolved out of a new consortium called FORGE Canada (Finding of Rare Disease Genes in Canada). It is funded by Genome Canada, Canadian Institutes of Health Research, Ontario Genomics Institute, Genome Québec and Genome British Columbia. Dr. Gibson is also supported by the Child & Family Research Institute (CFRI), and Dr. Steven Jones is supported by the Michael Smith Foundation for Health Research.

CFRI conducts discovery, clinical and applied research to benefit the health of children and families. It is the largest institute of its kind in Western Canada. CFRI works in close partnership with UBC, BC Children's Hospital and Sunny Hill Health Centre for Children, BC Women's Hospital & Health Centre, agencies of Provincial Health Services Authority (PHSA) and BC Children's Hospital Foundation. CFRI has additional important relationships with the province's five regional health authorities and with BC academic institutions SFU, the University of Victoria, the University of Northern British Columbia, and the British Columbia Institute of Technology. For more information, visit www.cfri.ca.

BC Children's Hospital, an agency of PHSA, provides expert care for the province's most seriously ill or injured children, including newborns and adolescents. BC Children's is an academic health centre affiliated with UBC, SFU, and CFRI. For more information, please visit www.bcchildrens.ca.

BC Cancer Agency, an agency of PHSA, is committed to reducing the incidence of cancer, reducing the mortality from cancer, and improving the quality of life of those living with cancer. It provides a comprehensive cancer control program for the people of British Columbia by working with community partners to deliver a range of oncology services, including prevention, early detection, diagnosis and treatment, research, education, supportive care, rehabilitation and palliative care. For more information, visit www.bccancer.ca.

UBC is one of Canada's largest and most prestigious public research and teaching institutions, and one of only two Canadian institutions to be consistently ranked among the world's 40 best universities. Surrounded by the beauty of the Canadian West, it is a place that inspires bold, new ways of thinking that have helped make it a national leader in areas as diverse as community service learning, sustainability and research commercialization. UBC attracts $550 million per year in research funding from government, non‐profit organizations and industry through 7,000 grants. For more information, visit www.ubc.ca

Original article: http://www.cfri.ca/news/media/gene-discovered-for-Weaver-syndrome.asp