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Pregnancy Timeline by SemestersFemale Reproductive SystemFertilizationThe Appearance of SomitesFirst TrimesterSecond TrimesterThird TrimesterFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterDevelopmental Timeline
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Home--History--Bibliography- -Pregnancy Timeline- Prescription Drugs/Pregnancy- Pregnancy Calculator - Reproductive System- -News Alerts

February 10, 2012--------News Archive Return to: News Alerts


Due to their findings, the researchers suggest management
as opposed to induced labor when possible.

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Induced Labor & Risk of Infection in Newborns

Researchers reported their findings suggesting that induced labor in patients with ruptured membranes (but before labor begins) between the 34th and 37th week of gestation, does not reduce the risk of infection or respiratory problems in the newborn

"Our research indicates that in patients who underwent close monitoring, known as expectant management, versus those whose labor was induced, there was no difference in the risk for infection in the newborn, breathing problems in the newborn or caesarean section rates," said David van der Ham, MD, with the Maastricht University Medical Center, Obstetrics & Gynecology, GROW School for Oncology and Developmental Biology, Maastricht, Netherlands, and one of the study's authors.

"Due to these findings, we suggested expectant management as opposed to induced labor when possible."

In the study, Induction of Labor Versus Expectant Management in Women with Preterm Prelabor Rupture of Membranes Between 34 and 37 Weeks– the PPROMEXIL-2 trial, van der Ham and his colleagues observed 536 women from January 2007 until September 2009, and 195 women from December 2009 until January 2011.

The study was performed in a multicenter setting within the Dutch obstetric research consortium, in which 60 hospitals in the Netherlands collaborated. After 24 hours of ruptured membranes, patients were allocated to either immediate delivery or expectant management until 37 weeks of gestational age.

Combined with results of all previous published trials there was no difference in the identified risks.


  • The research results indicate that:

    expectant management prolonged pregnancy for 3.5 days

    the risk for neonatal sepsis (infection of the newborn) overall was low (3.6%) and did not differ between treatment strategies

    the risk for respiratory distress syndrome (breathing problems of the newborn) did not differ between treatment strategies

    caesarean section rates were equal in both treatment strategies.

In addition to van der Ham, the study was conducted by Jantien van der Heijden and Hans van Beek, VieCuri Medical Center, Obstetrics & Gynecology, Venlo, Netherlands; Brent Opmeer, Academic Medical Center, Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam, Netherlands; Christine Willekes and Jan Nijhuis, Maastricht University Medical Center, Obstetrics & Gynecology, GROW School for Oncology and Developmental Biology, Maastricht, Netherlands; Twan Mulder, Maastricht University Medical Center, Pediatrics, Maastricht, Netherlands; Rob Moonen, Atrium Medical Center, Pediatrics, Heerlen, Netherlands; Marielle van Pampus, University Medical Center Groningen, Obstetrics and Gynecology, Groningen, Netherlands; Mariet Groenewout, University Medical Center Groningen, Obstetrics & Gynecology, Groningen, Netherlands; Gerald Mantel, Isala klinieken, Obstetrics & Gynecology, Zwolle, Netherlands; Anneke Kwee, Dutch consortium AMPHIA trial, Netherlands; Hajo Wildschut, Erasmus Medical Center, Obstetrics & Gynecology, Rotterdam, Netherlands; Bettina Akerboom, Albert Schweitzer Hospital, Obstetrics and Gynecology, Dordrecht, Netherlands; and Ben Mol, Academic Medical Center, Department of Obstetrics and Gynaecology, Amsterdam, Netherlands.

A copy of the abstract is available at http://www.smfmnewsroom.org/annual-meeting/2011-meeting-abstracts/. For interviews please contact Vicki Bendure at Vicki@bendurepr.com, 540-687-3360 (office) or 202-374-9259 (cell), or Jacqueline Boggess at jacqueline@bendurepr.com, 540-687-5399 (office) or 202-738-3054 (cell).

The Society for Maternal-Fetal Medicine (est. 1977) is a non-profit membership group for obstetricians/gynecologists who have additional formal education and training in maternal-fetal medicine. The society is devoted to reducing high-risk pregnancy complications by providing continuing education to its 2,000 members on the latest pregnancy assessment and treatment methods. It also serves as an advocate for improving public policy, and expanding research funding and opportunities for maternal-fetal medicine. The group hosts an annual scientific meeting in which new ideas and research in the area of maternal-fetal medicine are unveiled and discussed. For more information, visit www.smfm.org or www.facebook.com/SocietyforMaternalFetalMedicine.

Original article: https://www.smfm.org/default.cfm