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Pregnancy Timeline by SemestersFemale Reproductive SystemFertilizationThe Appearance of SomitesFirst TrimesterSecond TrimesterThird TrimesterFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterDevelopmental Timeline
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March 6, 2012--------News Archive Return to: News Alerts

In vitro fertilization (IVF) will sometimes use a micro-pipette to insert sperm within an egg.

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Discovery of Molecule Initiating Maturation of Eggs

Researchers have identified a molecule called Cdk1 that could lead to an increased rate of successful IVF

Up to 15% of all women of reproductive age struggle to become pregnant. In vitro fertilization (IVF) can help these women become mothers. However, women who are infertile because their eggs do not mature properly cannot be helped medically, as immature eggs cannot be fertilized.

In the future, such patients might be helped as a research group at the University of Gothenburg has found that the Cdk1 molecule has an important function in mammalian egg maturation. Their results have now been published in the journal Human Molecular Genetics.

"This is the first functional evidence that Cdk1 is a key molecule in mammalian egg maturation. If the results can be translated into clinical settings, it could possibly improve the chances of successful IVF treatment for women who today are not becoming pregnant because their eggs do not mature" says Kui Liu, professor at the Department of Chemistry and Molecular Biology, the University of Gothenburg, Sweden.

Kui Liu and his colleagues performed experiments on tissue-specific knockout mice. The results show that when the Cdk1 molecule was removed from eggs of mice, the egg maturation stopped. When the molecule was added again, maturation resumed.

Professor Liu is a professor in molecular biology at the Faculty of Science, University of Gothenburg, since February 2011. His research group specializes in studying the development of female germ cells. In the last few years he has been working on making his results useful for humans.

"We are eager to start tests on human eggs. Hopefully we can apply this in clinics within ten years" says Liu.

The article titled "Cdk1, But Not Cdk2, is the Sole Cdk that is Essential and Sufficient to Drive Resumption of Meiosis in Mouse Oocytes" was published in the journal Human Molecualar Genetics on 24 February 2012.

During IVF, eggs are taken out from the woman's ovary. The eggs are put together with sperm in a dish containing nutrient medium. The fertilized eggs are then transferred back to the woman to develop in the uterus. The world's first successful IVF was performed in the UK in 1978, and since then about two million children have been born through IVF. The first successful IVF in Scandinavia was performed at the Sahlgrenska University Hospital, Gothenburg, Sweden, in 1982. In Sweden about 2500 children are born through IVF every year.

Original article: http://www.eurekalert.org/pub_releases/2012-03/uog-doa030512.php