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Welcome to The Visible Embryo, a comprehensive educational resource on human development from conception to birth.

The Visible Embryo provides visual references for changes in fetal development throughout pregnancy and can be navigated via fetal development or maternal changes.

The National Institutes of Child Health and Human Development awarded Phase I and Phase II Small Business Innovative Research Grants to develop The Visible Embryo. Initally designed to evaluate the internet as a teaching tool for first year medical students, The Visible Embryo is linked to over 600 educational institutions and is viewed by more than ' million visitors each month.


WHO International Clinical Trials Registry Platform
The World Health Organization (WHO) has created a new Web site to help researchers, doctors and patients obtain reliable information on high-quality clinical trials. Now you can go to one website and search all registers to identify clinical trial research underway around the world!



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Disclaimer: The Visible Embryo web site is provided for your general information only. The information contained on this site should not be treated as a substitute for medical, legal or other professional advice. Neither is The Visible Embryo responsible or liable for the contents of any websites of third parties which are listed on this site.
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Pregnancy Timeline by SemestersFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresFemale Reproductive SystemEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterSecond TrimesterFirst TrimesterFertilizationDevelopmental Timeline
Click weeks 0 - 40 and follow fetal growth
Google Search artcles published since 2007
 
May 20, 2011--------News Archive

New Complexity In Genetic Diversity Of RNA
It turns out
RNA proteins do not precisely match the genes that encode them.

Validating Preschool Programs For Autism
Scientists from the Universities of Miami, North Carolina and Colorado, developed measures to evaluate teaching programs for autistic preschool children.


May 19, 2011--------News Archive

New Technique To 'Lift The Hood’ On Autism
A new study provides compelling evidence that exome-sequencing is an effective way to discover which of the 20,000 and more genes in the human genome are responsible for autism spectrum disorders.

Maternal Smoking Causes Changes In Fetal DNA
Children whose mothers or grandmothers smoked during pregnancy are at increased risk of asthma in childhood. A new study indicates changes in DNA methylation occuring before birth may be the root cause.


May 18, 2011--------News Archive

New Antiepileptic Drugs Don't Increase Birth Defects
Use of newer-generation antiepileptic drugs prescribed for bipolar mood disorders and migraine headaches, during the first trimester of pregnancy, are not associated with an increased risk of major birth defects in the first year of life in Denmark.

Neglect And Deprevation Age a Child's Chromosomes
Study of institutionalized Romanian children finds prematurely shortened telomeres, a mark of cell aging.


May 17, 2011--------News Archive

Older Fathers Linked to Autism In Children
Researchers sequenced protein-coding sections of affected childrens' genomes and their findings support population studies showing that autism is more common among children of older parents, especially older fathers.

Gene Variation Linked to Infertility in Women
A variation in a gene involved in regulating cholesterol also appears to affect progesterone in women, making it a likely culprit in cases of infertility.


May 16, 2011--------News Archive

Genetic Clue to Common Birth Defects Found
Scientists at King’s College London have for the first time uncovered a gene responsible for Adams-Oliver Syndrome, giving valuable insight into the possible genetic causes of common birth defects found in the wider population.

'Master switch' For Obesity and Diabetes Discovered
A gene linked to type 2 diabetes and cholesterol levels is in fact a 'master regulator' gene, which controls other genes found within fat in the body.

Tiny Change in One Gene May Explain Human Brain
The deep fissures and convolutions that increase the surface area and allow for rational and abstract thoughts of the human brain may be due to the LAMC3 gene.

Gene Change Can Get You Cancer Or Normal Growth
The deep fissures and convolutions that increase the surface area and allow for rational and abstract thoughts of the human brain may be due to one gene.


WHO Child Growth Charts

A variation in a gene involved in regulating cholesterol in the bloodstream also appears to affect progesterone production in women, making it a likely culprit in a substantial number of cases of female infertility, a new study from Johns Hopkins suggests.

The group also developed a simple blood test for that identifies the variation in the scavenger receptor class B type 1 gene (SCARB1) but emphasizes that no approved therapy as yet exists to address the problem in infertile women.

Follow up studies of female mice linked a deficiency in these receptors for HDL - the so called "good" or "healthy" cholesterol - and infertility. Researchers report finding the same link in studies of women with a history of infertility. With further investigation, the John Hopkins team believes their study will offer clues into a genetic cause, and could lead to infertility treatment for women based on results already shown to work in mice.

"Infertility is fairly common and a lot of the reasons for it are still unknown," says endocrinologist Annabelle Rodriguez, M.D., an associate professor of medicine at the Johns Hopkins University School of Medicine and the leader of the study published online in the journal Human Reproduction.

"Right now, the benefit of this research is in knowing that there might be a genetic reason for why some women have difficulty getting pregnant. In the future, we hope this knowledge can be translated into a cure for this type of infertility."

For three years, Rodriguez and her colleagues analyzed ovarian cells and fluid collected from 274 women unable to become pregnant and who were undergoing in-vitro fertilization (IVF). Some 207 went on to have their eggs collected, fertilized in a test tube and implanted in their wombs.

The scientists then measured whether there was evidence of a gestational sac or a fetal heartbeat 42 days after embryo transfer. Of the nine women in the group found to have a mutated SCARB1gene, none were pregnant.

Rodriguez says she believes the genetic variation could be present in 8 to 13 percent of the population.

Researchers also showed that all nine women with the mutated gene had low levels of progesterone, a hormone critical to sustaining pregnancy in its earliest stages, despite having received progesterone as part of the IVF process.

Rodriguez is director of the Johns Hopkins Diabetes and Cholesterol Metabolism Center, and based her research on mice genetically engineered without the receptor for good cholesterol. Without the receptor, the mice had abnormally high levels of HDL and were at increased risk for heart disease, as well as being infertile.

However, researchers at the Massachusetts Institute of Technology studying the genetically engineered mice have found a treatment for their infertility. A cholesterol medication developed decades ago called probucol, which lowered levels of cholesterol circulating in the blood and restored the rodents' fertility.

Probucol is no longer approved for use in the United States, partly because of concerns that it unsafely lowered HDL, the very "side effect" deemed good for mice with missing HDL receptors. In Japan Probucol is still available for use under some conditions.

"I'm an optimist that this drug or one like it could also restore fertility in women," Rodriguez says. "Everything else that was found in mice so far has borne out in humans."

Rodriguez hopes to conduct a clinical trial to see if probucol can help infertile women with the gene variation. She is also planning to collect data on HDL levels in infertile women with the genetic variation to see if that would prove to be an early clue to a genetic cause of their infertility.

This study was supported by a Burroughs Wellcome Clinical Scientist Award in Translational Research. Other researchers involved in the study, all of Johns Hopkins, are Melissa Yates, M.D., Antonia Kolmakova, Ph.D., and Yulian Zhao, M.D., Ph.D. Original article: http://www.eurekalert.org/pub_releases/2011-05/jhmi-gvl051611.php