Milk Ingredient Does a Waistline Good!
A natural ingredient found in milk protects against obesity
Just like people, mice enjoy diets that are high in fat. However, researchers, who liken the milk ingredient: nicotinamide riboside (NAD+) to a new kind of vitamin, observed that mice who were fed nicotinamide riboside along with a high fat diet, were not only protected from obesity - but became better at running as well.
A report of their findings appears in the June Cell Metabolism, a Cell Press publication.
"This [ingredient] is present in what we've all been eating since day one," says Johan Auwerx of École Polytechnique Fédérale de Lausanne.
The scientists identified the properties of nicotinamide riboside as they were searching for alternative ways to boost the well-known gene SIRT1. SIRT1 is known to benefit both metabolism and longevity. The researchers wanted to boost SIRT1- a red wine ingredient of resveratrol - for its' benefits to metabolism.
Auwerx's team suspected that a simpler way to boost SIRT1, would perhaps be through boosting levels of one of its' molecular sidekicks, the cofactor NAD+. This milk ingredient boosts SIRT1 in a rather appealing way. Not only is it a natural product, it also stays within the cell wall, as it does its magic.
Mice given nicotinamide riboside in fairly high doses along with their high-fat meals, burned more fat and were protected from obesity. They also become better runners, displaying muscles having greater endurance.
The benefits scientists observed in mice wouldn't be easy to get from drinking milk alone, Auwerx says. It may be more likely that the compound would serve as a new kind of metabolism-boosting supplement. Human tests are now needed.
Auwerx believes that NAD+ ultimately offers the same benefits attributed to resveratrol, just in a slightly different way.
Canto et al.: "The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity."
Original article: http://www.eurekalert.org/pub_releases/2012-06/cp-mid060112.php