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Pregnancy Timeline by SemestersFemale Reproductive SystemFertilizationThe Appearance of SomitesFirst TrimesterSecond TrimesterThird TrimesterFetal liver is producing blood cellsHead may position into pelvisBrain convolutions beginFull TermWhite fat begins to be madeWhite fat begins to be madeHead may position into pelvisImmune system beginningImmune system beginningPeriod of rapid brain growthBrain convolutions beginLungs begin to produce surfactantSensory brain waves begin to activateSensory brain waves begin to activateInner Ear Bones HardenBone marrow starts making blood cellsBone marrow starts making blood cellsBrown fat surrounds lymphatic systemFetal sexual organs visibleFinger and toe prints appearFinger and toe prints appearHeartbeat can be detectedHeartbeat can be detectedBasic Brain Structure in PlaceThe Appearance of SomitesFirst Detectable Brain WavesA Four Chambered HeartBeginning Cerebral HemispheresEnd of Embryonic PeriodEnd of Embryonic PeriodFirst Thin Layer of Skin AppearsThird TrimesterDevelopmental Timeline
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July 24, 2012--------News Archive Return to: News Alerts

It is hoped the results of this study will assist health care policy makers
in organizing regional and statewide care systems to more efficiently
provide the best care for premature infants within a geographical area.

WHO Child Growth Charts

       

Preemie Survival Rates Best in High-Level NICUs, Better than Previously Reported

Premature babies are more likely to survive when they are born in high-level neonatal intensive care units (NICUs) than in hospitals without such facilities, and this benefit is considerably larger than previously reported

The likelihood that an extremely premature baby will survive if born in a high-technology, high-volume hospital unit was already known, but the current study, the largest to date, revealed a stronger effect. Pediatric researchers who analyzed more than 1.3 million premature births over a 10-year span found that the survival benefits applied not only to extremely preterm babies, but also to moderately preterm newborns.

The research team performed a retrospective study of all hospital-based deliveries of infants with a gestational age between 23 and 37 weeks in Pennsylvania, California and Missouri—a total of over 1,328,000 births. The study focused on preterm deliveries in high-level NICUs, compared to preterm deliveries at all other hospitals.

"Prior studies from the early 1990s found increased survival rates of 30 to 50 percent among preterm infants delivered at high-level NICUs, compared to preterm infants delivered elsewhere," said study leader Scott A. Lorch, M.D., a neonatologist at The Children's Hospital of Philadelphia. "However, our research found rates as high as 300 percent improvement, when our study design controlled for the effect of sicker patients who typically deliver at high-level NICUs." Complication rates were similar for both types of hospitals.

The retrospective study, which appeared online July 9 in the journal Pediatrics, analyzed records for all births occurring between 1995 and 2005 in Pennsylvania and California, and all births between 1995 and 2003 in Missouri. Lorch added that the results varied slightly among the states, possibly reflecting state-level differences in health policies, such as whether or not the state government designated hospitals within a regional perinatal system.


Premature babies are those born before 37 weeks
gestational age (full term is 40 weeks).
In this study, the researchers defined extremely
preterm infants as those born before 32 weeks
and moderately preterm infants as those born
between 32 and 37 weeks.

They defined a high-level NICU as a level III
facility that delivered at least 50 very low
birth weight infants annually.

"We found survival benefits in high-level NICUs
for both extremely premature and moderately
premature infants," said Lorch.

"This suggests that the choice of a delivery hospital
may influence the outcomes for the full range
of preterm infants."


Unlike many previous analyses of birth outcomes, said Lorch, the current study covered more than a single state system. Using hospital data from states in three regions of the country suggests that the results may be more generalizable throughout the United States than in more limited studies, he added.

However, concluded Lorch, "this research does not imply that every hospital should aspire to build a high-tech NICU—there just aren't enough babies born prematurely for every birth hospital in the U.S. to have a high-level, high-volume NICU. Instead, the results may assist health care policy makers in organizing regional and statewide care systems to more efficiently provide the best care for premature infants within a geographical area."

Financial support for this study came from the Agency for Healthcare Research and Quality, part of the U.S. Department of Health and Human Services. Lorch's co-authors were Michael Baiocchi, Ph.D., and Dylan S. Small, Ph.D., of the University of Pennsylvania, and Corinne E. Ahlberg, M.S., of The Children's Hospital of Philadelphia. In addition to his position as an attending neonatologist at Children's Hospital, Lorch is also on the staff of the Hospital's Center for Outcomes Research and is a senior fellow at the Leonard Davis Institute of Health Economics at the University of Pennsylvania.

"The Differential Impact of Delivery Hospital on the Outcomes of Premature Infants," Pediatrics, published online July 9, 2012, and in print, August 2012. doi:10.1542/peds.2011-2820

About The Children's Hospital of Philadelphia: The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking third in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 516-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu.

Original article: http://www.eurekalert.org/pub_releases/2012-07/aga-apa072312.php