Pregnancy High Blood Pressure Link to DNA Methylation

Gene adaptations correspond to blood pressure increases at distinct intervals during pregnancy...

a^B and sporulation activity increase in a gradient, peaking at the top of the biofilm, even though a^B represses sporulation. As predicted by a simple mathematical model, increasing a^B expression shifts the peak of sporulation to the middle of the biofilm. Our results demonstrate how stochastic pulsing of gene expression can play a key role in pattern formation during biofilm development.

Authors
Eugene Nadezhdin, Niall Murphy, Neil Dalchau, Andrew Phillips and James C. W. Locke.

Acknowledgements
Funding for the work was provided by NICHD, the National Institute on Minority Health and Health Disparities and the National Institute of Diabetes and Digestive and Kidney Diseases, all part of NIH.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) leads research and training to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize abilities for all. For more information, visit https://www.nichd.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, read more or visit https://www.nih.gov.

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